García-Escobar Eva, Soriguer Federico, García-Serrano Sara, Gómez-Zumaquero Juan M, Morcillo Sonsoles, Haro Juan, Rojo-Martínez Gemma
Servicio de Endocrinología y Nutrición, Hospital Universitario Carlos Haya, Málaga, Spain.
J Nutr Biochem. 2008 Nov;19(11):727-31. doi: 10.1016/j.jnutbio.2007.09.007. Epub 2008 Mar 6.
Although various studies have noted fatty-acid-mediated regulation of adipocyte lipolysis, determining the isolated effect of a single fatty acid is more difficult. We examined the influence of dietary oleic acid on adipose cell lipolytic activity and the tissue fat content independently of the variation in other dietary fatty acids. We fed 48 rats with six diets designed so that the oleic acid content was not correlated with the content of any other fatty acid and studied the lipolytic activity and fatty acid content of the tissues. There were no differences in the weight of the animals after the diet. The muscle fat content and the epinephrine-stimulated lipolytic activity varied significantly according to the dietary levels of oleic acid and the tissues, showing a dose-dependent behavior of the dietary oleic acid concentration. The results of this study show that diets rich in oleic acid have a beneficial effect on the regulation of lipid metabolism and body weight homeostasis.
尽管多项研究已指出脂肪酸对脂肪细胞脂解的调节作用，但确定单一脂肪酸的独立作用更为困难。我们研究了膳食油酸对脂肪细胞脂解活性和组织脂肪含量的影响，且不考虑其他膳食脂肪酸的变化。我们用六种饮食喂养48只大鼠，这些饮食的设计使得油酸含量与任何其他脂肪酸的含量均无关联，并研究了组织的脂解活性和脂肪酸含量。饮食后动物体重没有差异。肌肉脂肪含量和肾上腺素刺激的脂解活性根据膳食油酸水平和组织的不同而有显著变化，呈现出膳食油酸浓度的剂量依赖性。本研究结果表明，富含油酸的饮食对脂质代谢调节和体重稳态具有有益作用。
