de Mathis Maria Alice, do Rosario Maria Conceição, Diniz Juliana Belo, Torres Albina Rodrigues, Shavitt Roseli Gedanki, Ferrão Ygor Arzeno, Fossaluza Victor, de Bragança Pereira Carlos Alberto, Miguel Eurípedes Constantino
Department of Psychiatry, University of Sao Paulo Medical School, Rua Dr. Ovídio Pires de Campos, 785, 05403-010 São Paulo, SP, Brazil.
Eur Psychiatry. 2008 Apr;23(3):187-94. doi: 10.1016/j.eurpsy.2008.01.002. Epub 2008 Mar 7.
This study investigates the influence of age at onset of OCS on psychiatric comorbidities, and tries to establish a cut-off point for age at onset.
Three hundred and thirty OCD patients were consecutively recruited and interviewed using the following structured interviews: Yale-Brown Obsessive Compulsive Scale; Yale Global Tic Severity Scale and the Structured Clinical Interview for DSM-IV. Data were analyzed with regression and cluster analysis.
Lower age at onset was associated with a higher probability of having comorbidity with tic, anxiety, somatoform, eating and impulse-control disorders. Longer illness duration was associated with lower chance of having tics. Female gender was associated with anxiety, eating and impulse-control disorders. Tic disorders were associated with anxiety disorders and attention-deficit/hyperactivity disorder. No cut-off age at onset was found to clearly divide the sample in homogeneous subgroups. However, cluster analyses revealed that differences started to emerge at the age of 10 and were more pronounced at the age of 17, suggesting that these were the best cut-off points on this sample.
Age at onset is associated with specific comorbidity patterns in OCD patients. More prominent differences are obtained when analyzing age at onset as an absolute value.
本研究调查强迫症（OCD）起病年龄对精神共病的影响，并试图确定起病年龄的分界点。
连续招募330例强迫症患者，并使用以下结构化访谈进行面谈：耶鲁-布朗强迫症量表、耶鲁综合抽动严重程度量表和DSM-IV结构化临床访谈。采用回归分析和聚类分析对数据进行分析。
起病年龄较低与患抽动、焦虑、躯体形式、饮食和冲动控制障碍共病的可能性较高相关。病程较长与患抽动的几率较低相关。女性与焦虑、饮食和冲动控制障碍相关。抽动障碍与焦虑障碍和注意力缺陷多动障碍相关。未发现能将样本清晰分为同质亚组的起病年龄分界点。然而，聚类分析显示差异在10岁开始出现，在17岁时更为明显，这表明这是该样本的最佳分界点。
起病年龄与强迫症患者特定的共病模式相关。将起病年龄作为绝对值进行分析时，会获得更显著的差异。
