• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Hop1与减数分裂DNA损伤反应

Hop1 and the meiotic DNA-damage response.

作者信息

Hunter Neil

机构信息

Section of Microbiology, University of California Davis, Davis, CA 95616, USA.

出版信息

Cell. 2008 Mar 7;132(5):731-2. doi: 10.1016/j.cell.2008.02.026.

DOI:10.1016/j.cell.2008.02.026
PMID:18329359
Abstract

During the DNA-damage response, adaptor proteins mediate signaling between the PI3K-like sensor kinases, ATM and ATR, and serine/threonine effector kinases. Carballo et al. (2008) now show that the chromosomal protein Hop1 mediates PI3K-like kinase signaling during the repair of DNA double-strand breaks (DSBs) in meiosis.

摘要

在DNA损伤反应过程中，衔接蛋白介导PI3K样传感激酶、ATM和ATR与丝氨酸/苏氨酸效应激酶之间的信号传导。卡瓦略等人（2008年）现在表明，染色体蛋白Hop1在减数分裂过程中DNA双链断裂（DSB）修复期间介导PI3K样激酶信号传导。

相似文献

1
Hop1 and the meiotic DNA-damage response.Hop1与减数分裂DNA损伤反应
Cell. 2008 Mar 7;132(5):731-2. doi: 10.1016/j.cell.2008.02.026.
2
Phosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination.Mec1/Tel1对轴向元件蛋白Hop1的磷酸化作用确保了减数分裂中的同源重组。
Cell. 2008 Mar 7;132(5):758-70. doi: 10.1016/j.cell.2008.01.035.
3
Essential and Checkpoint Functions of Budding Yeast ATM and ATR during Meiotic Prophase Are Facilitated by Differential Phosphorylation of a Meiotic Adaptor Protein, Hop1.减数分裂前期出芽酵母ATM和ATR的基本功能及检查点功能由减数分裂衔接蛋白Hop1的差异磷酸化促进。
PLoS One. 2015 Jul 30;10(7):e0134297. doi: 10.1371/journal.pone.0134297. eCollection 2015.
4
Selective binding of meiosis-specific yeast Hop1 protein to the holliday junctions distorts the DNA structure and its implications for junction migration and resolution.减数分裂特异性酵母Hop1蛋白与霍利迪连接点的选择性结合会扭曲DNA结构及其对连接点迁移和拆分的影响。
J Mol Biol. 2006 Dec 8;364(4):599-611. doi: 10.1016/j.jmb.2006.08.096. Epub 2006 Sep 14.
5
Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage.Esc4p是Mec1p（ATR）的一个新靶点，可促进DNA损伤后DNA合成的恢复。
EMBO J. 2004 Mar 10;23(5):1188-97. doi: 10.1038/sj.emboj.7600129. Epub 2004 Feb 26.
6
Mnd1/Hop2 facilitates Dmc1-dependent interhomolog crossover formation in meiosis of budding yeast.Mnd1/Hop2促进芽殖酵母减数分裂中依赖Dmc1的同源染色体交叉形成。
Mol Cell Biol. 2006 Apr;26(8):2913-23. doi: 10.1128/MCB.26.8.2913-2923.2006.
7
DNA double-strand breaks in meiosis: checking their formation, processing and repair.减数分裂中的DNA双链断裂：检查其形成、加工和修复
DNA Repair (Amst). 2009 Sep 2;8(9):1127-38. doi: 10.1016/j.dnarep.2009.04.005. Epub 2009 May 22.
8
Role of the Saccharomyces cerevisiae Rad53 checkpoint kinase in signaling double-strand breaks during the meiotic cell cycle.酿酒酵母Rad53检查点激酶在减数分裂细胞周期中双链断裂信号传导中的作用。
Mol Cell Biol. 2008 Jul;28(14):4480-93. doi: 10.1128/MCB.00375-08. Epub 2008 May 27.
9
Mek1 stabilizes Hop1-Thr318 phosphorylation to promote interhomolog recombination and checkpoint responses during yeast meiosis.Mek1 通过稳定 Hop1-Thr318 的磷酸化来促进同源重组和有丝分裂检查点反应。
Nucleic Acids Res. 2012 Dec;40(22):11416-27. doi: 10.1093/nar/gks920. Epub 2012 Oct 9.
10
gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes.γH2AX和MDC1：将DNA损伤反应机制锚定到断裂的染色体上。
DNA Repair (Amst). 2006 May 10;5(5):534-43. doi: 10.1016/j.dnarep.2006.01.012. Epub 2006 Mar 10.

引用本文的文献

1
A chromatin-associated protein required for inducing and limiting meiotic DNA double-strand break formation.一种与染色质相关的蛋白质，对于诱导和限制减数分裂 DNA 双链断裂的形成是必需的。
Nucleic Acids Res. 2018 Dec 14;46(22):11822-11834. doi: 10.1093/nar/gky968.
2
The meiotic checkpoint network: step-by-step through meiotic prophase.减数分裂检查点网络：逐步贯穿减数分裂前期
Cold Spring Harb Perspect Biol. 2014 Oct 1;6(10):a016675. doi: 10.1101/cshperspect.a016675.
3
Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor.
依赖 Dot1 的组蛋白 H3K79 甲基化通过调节 Hop1 衔接蛋白促进 Mek1 减数分裂检查点效应激酶的激活。
PLoS Genet. 2013;9(1):e1003262. doi: 10.1371/journal.pgen.1003262. Epub 2013 Jan 31.
4
MU2 and HP1a regulate the recognition of double strand breaks in Drosophila melanogaster.MU2 和 HP1a 调控黑腹果蝇中双链断裂的识别。
PLoS One. 2011;6(9):e25439. doi: 10.1371/journal.pone.0025439. Epub 2011 Sep 23.
5
Trying to avoid your sister. 试图避开你姐姐。
PLoS Biol. 2010 Oct 19;8(10):e1000519. doi: 10.1371/journal.pbio.1000519.
6
Tetrahymena meiotic nuclear reorganization is induced by a checkpoint kinase-dependent response to DNA damage.四膜虫减数分裂核重组是由对DNA损伤的检查点激酶依赖性反应诱导的。
Mol Biol Cell. 2009 May;20(9):2428-37. doi: 10.1091/mbc.e08-10-1058. Epub 2009 Mar 18.