Dustin Michael L
Helen L. and Martin S. Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Cell. 2008 Mar 7;132(5):733-4. doi: 10.1016/j.cell.2008.02.016.
Cell polarity is critical for T lymphocyte movement during their hunt for antigen-bearing cells and for infected target cells. In this issue of Cell, Yeh et al. (2008) now reveal a direct link between T cell polarity and the production of proinflammatory cytokines in mice lacking the class I MHC-restricted T cell-associated molecule (Crtam).
细胞极性对于T淋巴细胞寻找携带抗原的细胞以及被感染的靶细胞过程中的移动至关重要。在本期《细胞》杂志中，Yeh等人（2008年）现在揭示了在缺乏I类主要组织相容性复合体（MHC）限制的T细胞相关分子（Crtam）的小鼠中，T细胞极性与促炎细胞因子产生之间的直接联系。
