Wilkinson G S, Dreyer N A
Epidemiology Resources Inc., Chestnut Hill, MA.
Epidemiology. 1991 Jul;2(4):305-9. doi: 10.1097/00001648-199107000-00013.
We conducted an analysis of leukemia mortality and protracted exposure to low-dose ionizing radiation. We used data from seven published epidemiologic studies of nuclear workers that reported individual monitoring information for radiation exposure. We found 83 leukemia deaths among white males from a combined total of more than 1.4 million person-years. We calculated an overall relative risk for leukemia of 1.5, after adjustment for age and calendar time, for workers with cumulative occupational doses of 10 mSv (1 rem) or greater, compared with those with cumulative doses of less than 10 mSv. An adjusted relative risk of 1.8 was observed when individuals with 10-50 mSv (1-5 rem) were compared with those who had cumulative occupational doses of less than 10 mSv. The adjusted relative risk for those with doses greater than 50 mSv relative to those with doses less than 10 mSv was 1.2, although the data were especially sparse in this dose range. These combined data indicate a small elevated risk of leukemia for doses of ionizing radiation under 50 mSv.
我们对白血病死亡率以及长期暴露于低剂量电离辐射的情况进行了分析。我们使用了七项已发表的核工业工人流行病学研究的数据，这些研究报告了辐射暴露的个人监测信息。在总计超过140万人年的观察中，我们发现白人男性中有83例白血病死亡病例。在对年龄和日历时间进行调整后，我们计算出累积职业剂量达到10毫希沃特（1雷姆）或更高的工人患白血病的总体相对风险为1.5，而累积剂量低于10毫希沃特的工人相对风险为1。当将累积剂量在10 - 50毫希沃特（1 - 5雷姆）之间的个体与累积职业剂量低于10毫希沃特的个体进行比较时，观察到调整后的相对风险为1.8。相对于累积剂量低于10毫希沃特的个体，累积剂量大于50毫希沃特的个体调整后的相对风险为1.2，尽管在该剂量范围内的数据特别稀少。这些综合数据表明，电离辐射剂量低于50毫希沃特时白血病风险略有升高。
