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在分解代谢状态下，细胞凋亡信号传导在骨骼肌萎缩过程中至关重要且先于蛋白质降解。

Apoptosis signalling is essential and precedes protein degradation in wasting skeletal muscle during catabolic conditions.

作者信息

Argilés Josep M, López-Soriano Francisco J, Busquets Sílvia

机构信息

Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, 08028 Barcelona, Spain.

出版信息

Int J Biochem Cell Biol. 2008;40(9):1674-8. doi: 10.1016/j.biocel.2008.02.001. Epub 2008 Feb 14.

DOI:10.1016/j.biocel.2008.02.001
PMID:18329944
Abstract

Activation of skeletal muscle proteolysis leads to wasting in many types of catabolic/chronic diseases. Protein breakdown is basically accomplished by the activation of the ubiquitin-proteasome system. Interestingly, several publications have shown that DNA fragmentation also occurs in skeletal muscle tissue during catabolism. The present review suggests that activation of apoptosis precedes protein breakdown associated with muscle wasting. In addition, the role of the different proteolytic systems and their relation with apoptosis is emphasized. Altogether, the data presented could be used for the design of new approaches for the treatment of muscle wasting diseases.

摘要

骨骼肌蛋白水解的激活会导致多种分解代谢/慢性疾病中的肌肉萎缩。蛋白质分解基本上是通过泛素-蛋白酶体系统的激活来完成的。有趣的是，一些出版物表明，在分解代谢过程中，骨骼肌组织中也会发生DNA片段化。本综述表明，细胞凋亡的激活先于与肌肉萎缩相关的蛋白质分解。此外，还强调了不同蛋白水解系统的作用及其与细胞凋亡的关系。总之，所呈现的数据可用于设计治疗肌肉萎缩疾病的新方法。

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