Lin Xiu-Lan, Lin Na, Liu Chun-Fang, Liu Yuan, Liang Zhi-Ran, Wan Rong, Kong Xiang-Ying
People's Hospital of Guigang, Guigang 537100, China.
Zhongguo Zhong Yao Za Zhi. 2007 Dec;32(23):2543-6.
To investigate the effect of Coptis chinensis on jaundice of G6PD deficient neonates.
122 G6PD deficient neonates with jaundice who were in People' s Hospital of Guigang of Guangxi province from January 1999 to October 2004 were divided into two groups: C. chinensis group (62 neonates with C. chinensis administration before jaundice' s appearance) and none C. chinensis group (60 neonates without C. chinensis administration before jaundice' s appearance). The initial time, duration of jaundice, hemoglobin and serum bilirubin level and the incidence of kernicterus were analyzed between the two groups.
The initial time of jaundice is significantly later and the duration of jaundice is markedly shorter in the neonates with C. chinensis than that without C. chinensis. Simultaneously, the level of hemoglobin is significantly increased, and there is a low tendency of serum total bilirubin and direct bilirubin level in C. chinensis group as compared to that in none C. chinensis group. Moreover, there is no kernicterus in C. chinensis group and no difference in the treating result out of hospital between the two groups.
Our results do not support the view that C. chinensis could aggravate jaundice of G6PD deficient neonates.
探讨黄连对葡萄糖-6-磷酸脱氢酶（G6PD）缺乏的新生儿黄疸的影响。
选取1999年1月至2004年10月在广西贵港市人民医院住院的122例G6PD缺乏且伴有黄疸的新生儿，分为两组：黄连组（62例在黄疸出现前给予黄连治疗的新生儿）和非黄连组（60例在黄疸出现前未给予黄连治疗的新生儿）。分析两组患儿黄疸出现的初始时间、黄疸持续时间、血红蛋白及血清胆红素水平以及核黄疸的发生率。
黄连组新生儿黄疸出现的初始时间明显延迟，黄疸持续时间明显缩短。同时，血红蛋白水平显著升高，与非黄连组相比，黄连组血清总胆红素和直接胆红素水平有降低趋势。此外，黄连组无核黄疸发生，两组出院时治疗效果无差异。
我们的结果不支持黄连会加重G6PD缺乏新生儿黄疸这一观点。
