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Effects of nicotinic agonists on the NMDA receptor.

作者信息

Aizenman E, Tang L H, Reynolds I J

机构信息

Department of Physiology, University of Pittsburgh School of Medicine, PA 15261.

出版信息

Brain Res. 1991 Jun 14;551(1-2):355-7. doi: 10.1016/0006-8993(91)90958-x.

DOI:10.1016/0006-8993(91)90958-x
PMID:1833030
Abstract

The cholinergic nicotinic agonists (-)nicotine and lobeline were observed to partially inhibit whole-cell N-methyl-D-aspartate (NMDA)-induced responses in rat cortical neurons in culture. In addition we found that (-)nicotine, (+)nicotine, and lobeline, but not the nicotine metabolite (-)cotinine nor acetylcholine, were able to displace [3H]dizocilpine ([3H]MK 801) binding in well-washed membranes obtained from rat brain. These results show that certain nicotinic agonists can interact with the NMDA receptor and block its function.

摘要

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