心房利钠肽可抑制肾小球疾病和原发性高血压患者对甲氧氯普胺的醛固酮反应。

Atrial natriuretic peptide inhibits the aldosterone response to metoclopramide in patients with glomerular disease and essential hypertension.

Matsuoka H, Fukui K, Dan Y, Ishimitsu T, Hirata Y, Kimura K, Sugimoto T, Ishii M, Kangawa K, Matsuo H

Second Department of Internal Medicine, University of Tokyo, Japan.

Clin Exp Pharmacol Physiol. 1991 Aug;18(8):557-62. doi: 10.1111/j.1440-1681.1991.tb01491.x.

Abstract

We examined the effects of metoclopramide (MCP: 10 mg i.v.) on plasma atrial natriuretic peptide (ANP) and aldosterone concentrations (PAC) and the effect of ANP on MCP-induced PAC in four patients with primary glomerular diseases and seven patients with essential hypertension. 2. MCP injection caused no significant changes in plasma ANP. MCP produced a marked increase in PAC without a significant change in plasma renin activity. 3. The increase in PAC induced by MCP injection was markedly attenuated when preceded by the infusion of ANP (25 ng/kg per min). 4. These results suggest that the dopaminergic D2 mechanism is not involved in the regulation of ANP secretion and that ANP modulates the dopaminergic regulation of aldosterone secretion.

摘要

我们研究了甲氧氯普胺（MCP：静脉注射10毫克）对4例原发性肾小球疾病患者和7例原发性高血压患者血浆心钠素（ANP）及醛固酮浓度（PAC）的影响，以及ANP对MCP诱导的PAC的影响。2. 注射MCP后血浆ANP无显著变化。MCP使PAC显著升高，而血浆肾素活性无显著改变。3. 在注射ANP（每分钟25纳克/千克）后再注射MCP，MCP诱导的PAC升高明显减弱。4. 这些结果表明，多巴胺能D2机制不参与ANP分泌的调节，且ANP可调节醛固酮分泌的多巴胺能调节。