含有σ54启动子特异性因子的细菌RNA聚合酶的作用方式。
Modus operandi of the bacterial RNA polymerase containing the sigma54 promoter-specificity factor.
作者信息
Wigneshweraraj Sivaramesh, Bose Daniel, Burrows Patricia C, Joly Nicolas, Schumacher Jörg, Rappas Mathieu, Pape Tillmann, Zhang Xiaodong, Stockley Peter, Severinov Konstantin, Buck Martin
机构信息
Department of Microbiology, Division of Investigative Sciences, Faculty of Medicine and Centre for Molecular Microbiology and Infection, Imperial College London, SW7 2AZ, UK.
出版信息
Mol Microbiol. 2008 May;68(3):538-46. doi: 10.1111/j.1365-2958.2008.06181.x. Epub 2008 Mar 4.
Bacterial sigma (sigma) factors confer gene specificity upon the RNA polymerase, the central enzyme that catalyses gene transcription. The binding of the alternative sigma factor sigma(54) confers upon the RNA polymerase special functional and regulatory properties, making it suited for control of several major adaptive responses. Here, we summarize our current understanding of the interactions the sigma(54) factor makes with the bacterial transcription machinery.
细菌的σ因子赋予RNA聚合酶基因特异性，RNA聚合酶是催化基因转录的核心酶。替代σ因子σ54的结合赋予RNA聚合酶特殊的功能和调控特性，使其适合控制几种主要的适应性反应。在此，我们总结了目前对σ54因子与细菌转录机制相互作用的理解。
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