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Interaction of flunarizine with dopamine D2 and D1 receptors.

作者信息

Ambrosio C, Stefanini E

机构信息

Department of Neuroscience B.B. Brodie, University of Cagliari, Italy.

出版信息

Eur J Pharmacol. 1991 May 17;197(2-3):221-3. doi: 10.1016/0014-2999(91)90526-v.

DOI:10.1016/0014-2999(91)90526-v
PMID:1833208
Abstract

Flunarizine dose dependently inhibits the binding of both [3H]spiperone and [3H]SCH 23390 with Ki values of 112 +/- 9 and 532 +/- 39 nM, respectively. The inhibition of [3H]spiperone binding by flunarizine was competitive as revealed by the Schild plot. The results indicate that flunarizine is a fairly potent dopamine D2 receptor antagonist and offer a possible explanation for the extrapyramidal side-effects observed in patients treated with the drug.

摘要

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