丁硫氨酸亚砜亚胺在急性恰加斯病小鼠模型中具有抗克氏锥虫活性，并能增强硝呋替莫的疗效。
Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox.
作者信息
Faúndez Mario, López-Muñoz Rodrigo, Torres Gloria, Morello Antonio, Ferreira Jorge, Kemmerling Ulrike, Orellana Myriam, Maya Juan D
机构信息
Program of Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile.
出版信息
Antimicrob Agents Chemother. 2008 May;52(5):1837-9. doi: 10.1128/AAC.01454-07. Epub 2008 Mar 10.
Abstract
L-buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden in the hearts. Treatment with BSO plus nifurtimox caused an increase in the survival rate in comparison to the rates with treatment with each drug alone.
摘要
以220毫克/千克体重/天的剂量给予L-丁硫氨酸（S，R）-亚砜亚胺（BSO）对感染克氏锥虫的小鼠显示出抗锥虫效果，提高了它们的存活率，并降低了心脏中的寄生虫血症和寄生虫负荷。与单独使用每种药物治疗的存活率相比，用BSO加硝呋莫司治疗使存活率有所提高。
相似文献
1
Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox.
Antimicrob Agents Chemother. 2008 May;52(5):1837-9. doi: 10.1128/AAC.01454-07. Epub 2008 Mar 10.
2
Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi.
Antimicrob Agents Chemother. 2005 Jan;49(1):126-30. doi: 10.1128/AAC.49.1.126-130.2005.
3
Effects of buthionine sulfoximine nifurtimox and benznidazole upon trypanothione and metallothionein proteins in Trypanosoma cruzi.
Biol Res. 2004;37(1):61-9. doi: 10.4067/s0716-97602004000100007.
4
[Nifurtimox, a bright future for treatment of Chagas disease].
Med Trop (Mars). 2011 Apr;71(2):131-3.
5
Molecular and biological characterization of a highly pathogenic Trypanosoma cruzi strain isolated from a patient with congenital infection.
Exp Parasitol. 2018 Mar;186:50-58. doi: 10.1016/j.exppara.2018.02.002. Epub 2018 Feb 13.
6
Effects of astaxanthin in mice acutely infected with Trypanosoma cruzi.
Parasite. 2017;24:17. doi: 10.1051/parasite/2017018. Epub 2017 May 31.
7
Anti-parasitic effect of vitamin C alone and in combination with benznidazole against Trypanosoma cruzi.
PLoS Negl Trop Dis. 2018 Sep 21;12(9):e0006764. doi: 10.1371/journal.pntd.0006764. eCollection 2018 Sep.
8
[Treatment of Chagas' disease].
Rev Med Chil. 1985 Feb;113(2):162-6.
9
Antiprotozoal drug nitazoxanide enhances parasitemia, tissue lesions and mortality caused by Trypanosoma cruzi in murine model.
Exp Parasitol. 2017 Jan;172:44-50. doi: 10.1016/j.exppara.2016.12.013. Epub 2016 Dec 21.
10
Nifurtimox response of isolates from an outbreak of Chagas disease in Caracas, Venezuela.
J Vector Borne Dis. 2019 Jul-Sep;56(3):237-243. doi: 10.4103/0972-9062.289397.
引用本文的文献
1
Buthionine sulfoximine increases the efficacy of arteether antimalarial activity in arteether-resistant by glutathione depletion.
Malariaworld J. 2015 Apr 30;6:4. doi: 10.5281/zenodo.10870048. eCollection 2015.
2
The repositioned drugs disulfiram/diethyldithiocarbamate combined to benznidazole: Searching for Chagas disease selective therapy, preventing toxicity and drug resistance.
Front Cell Infect Microbiol. 2022 Jul 29;12:926699. doi: 10.3389/fcimb.2022.926699. eCollection 2022.
3
Intrinsic and Chemotherapeutic Stressors Modulate ABCC-Like Transport in .
Molecules. 2021 Jun 9;26(12):3510. doi: 10.3390/molecules26123510.
4
Advances in preclinical approaches to Chagas disease drug discovery.
Expert Opin Drug Discov. 2019 Nov;14(11):1161-1174. doi: 10.1080/17460441.2019.1652593. Epub 2019 Aug 14.
5
Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment.
Mem Inst Oswaldo Cruz. 2018 Mar;113(3):153-160. doi: 10.1590/0074-02760170267.
6
Dipyridamole potentiated the trypanocidal effect of nifurtimox and improved the cardiac function in NMRI mice with acute chagasic myocarditis.
Mem Inst Oswaldo Cruz. 2017 Sep;112(9):596-608. doi: 10.1590/0074-02760160499.
7
Synthetic Medicinal Chemistry in Chagas' Disease: Compounds at The Final Stage of "Hit-To-Lead" Phase.
Pharmaceuticals (Basel). 2010 Mar 25;3(4):810-838. doi: 10.3390/ph3040810.
8
Nifurtimox Is Effective Against Neural Tumor Cells and Is Synergistic with Buthionine Sulfoximine.
Sci Rep. 2016 Jun 10;6:27458. doi: 10.1038/srep27458.
9
Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics.
PLoS Negl Trop Dis. 2014 May 22;8(5):e2844. doi: 10.1371/journal.pntd.0002844. eCollection 2014 May.
10
Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments.
PLoS Negl Trop Dis. 2013 Aug 15;7(8):e2367. doi: 10.1371/journal.pntd.0002367. eCollection 2013.
本文引用的文献
1
Chagas disease.
Postgrad Med J. 2006 Dec;82(974):788-98. doi: 10.1136/pgmj.2006.047357.
2
Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host.
Comp Biochem Physiol A Mol Integr Physiol. 2007 Apr;146(4):601-20. doi: 10.1016/j.cbpa.2006.03.004. Epub 2006 Mar 12.
3
Glutathione in cancer biology and therapy.
Crit Rev Clin Lab Sci. 2006;43(2):143-81. doi: 10.1080/10408360500523878.
4
Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi.
Antimicrob Agents Chemother. 2005 Jan;49(1):126-30. doi: 10.1128/AAC.49.1.126-130.2005.
5
Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage.
Antimicrob Agents Chemother. 2003 Oct;47(10):3368-70. doi: 10.1128/AAC.47.10.3368-3370.2003.
6
Thiol-based redox metabolism of protozoan parasites.
Trends Parasitol. 2003 Jul;19(7):320-8. doi: 10.1016/s1471-4922(03)00141-7.
7
Trypanosoma cruzi: effect and mode of action of nitroimidazole and nitrofuran derivatives.
Biochem Pharmacol. 2003 Mar 15;65(6):999-1006. doi: 10.1016/s0006-2952(02)01663-5.
8
A critical review on Chagas disease chemotherapy.
Mem Inst Oswaldo Cruz. 2002 Jan;97(1):3-24. doi: 10.1590/s0074-02762002000100001.
9
Free radicals in the physiological control of cell function.
Physiol Rev. 2002 Jan;82(1):47-95. doi: 10.1152/physrev.00018.2001.
10
Ovothiol and trypanothione as antioxidants in trypanosomatids.
Mol Biochem Parasitol. 2001 Jul;115(2):189-98. doi: 10.1016/s0166-6851(01)00285-7.
Zotero 插件