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本文引用的文献

1
Chagas disease.恰加斯病
Postgrad Med J. 2006 Dec;82(974):788-98. doi: 10.1136/pgmj.2006.047357.
2
Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host.天然和合成药物对克氏锥虫的作用模式及其与哺乳动物宿主的相互作用。
Comp Biochem Physiol A Mol Integr Physiol. 2007 Apr;146(4):601-20. doi: 10.1016/j.cbpa.2006.03.004. Epub 2006 Mar 12.
3
Glutathione in cancer biology and therapy.癌症生物学与治疗中的谷胱甘肽
Crit Rev Clin Lab Sci. 2006;43(2):143-81. doi: 10.1080/10408360500523878.
4
Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi.丁硫氨酸亚砜亚胺增加了硝呋替莫和苯硝唑对克氏锥虫的毒性。
Antimicrob Agents Chemother. 2005 Jan;49(1):126-30. doi: 10.1128/AAC.49.1.126-130.2005.
5
Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage.美他唑（一种杀锥虫的硝基咪唑）的活性与DNA损伤有关。
Antimicrob Agents Chemother. 2003 Oct;47(10):3368-70. doi: 10.1128/AAC.47.10.3368-3370.2003.
6
Thiol-based redox metabolism of protozoan parasites.原生动物寄生虫基于硫醇的氧化还原代谢。
Trends Parasitol. 2003 Jul;19(7):320-8. doi: 10.1016/s1471-4922(03)00141-7.
7
Trypanosoma cruzi: effect and mode of action of nitroimidazole and nitrofuran derivatives.克氏锥虫：硝基咪唑和硝基呋喃衍生物的作用效果及作用方式
Biochem Pharmacol. 2003 Mar 15;65(6):999-1006. doi: 10.1016/s0006-2952(02)01663-5.
8
A critical review on Chagas disease chemotherapy.关于恰加斯病化疗的批判性综述。
Mem Inst Oswaldo Cruz. 2002 Jan;97(1):3-24. doi: 10.1590/s0074-02762002000100001.
9
Free radicals in the physiological control of cell function.细胞功能生理调控中的自由基
Physiol Rev. 2002 Jan;82(1):47-95. doi: 10.1152/physrev.00018.2001.
10
Ovothiol and trypanothione as antioxidants in trypanosomatids.作为锥虫抗氧化剂的卵硫醇和锥虫硫醇
Mol Biochem Parasitol. 2001 Jul;115(2):189-98. doi: 10.1016/s0166-6851(01)00285-7.

丁硫氨酸亚砜亚胺在急性恰加斯病小鼠模型中具有抗克氏锥虫活性，并能增强硝呋替莫的疗效。

Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox.

作者信息

Faúndez Mario, López-Muñoz Rodrigo, Torres Gloria, Morello Antonio, Ferreira Jorge, Kemmerling Ulrike, Orellana Myriam, Maya Juan D

机构信息

Program of Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile.

出版信息

Antimicrob Agents Chemother. 2008 May;52(5):1837-9. doi: 10.1128/AAC.01454-07. Epub 2008 Mar 10.

DOI:10.1128/AAC.01454-07
PMID:18332173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2346639/
Abstract

L-buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden in the hearts. Treatment with BSO plus nifurtimox caused an increase in the survival rate in comparison to the rates with treatment with each drug alone.

摘要

以220毫克/千克体重/天的剂量给予L-丁硫氨酸（S，R）-亚砜亚胺（BSO）对感染克氏锥虫的小鼠显示出抗锥虫效果，提高了它们的存活率，并降低了心脏中的寄生虫血症和寄生虫负荷。与单独使用每种药物治疗的存活率相比，用BSO加硝呋莫司治疗使存活率有所提高。