丁硫氨酸亚砜亚胺在急性恰加斯病小鼠模型中具有抗克氏锥虫活性，并能增强硝呋替莫的疗效。
Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox.
作者信息
Faúndez Mario, López-Muñoz Rodrigo, Torres Gloria, Morello Antonio, Ferreira Jorge, Kemmerling Ulrike, Orellana Myriam, Maya Juan D
机构信息
Program of Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile.
出版信息
Antimicrob Agents Chemother. 2008 May;52(5):1837-9. doi: 10.1128/AAC.01454-07. Epub 2008 Mar 10.
Abstract
L-buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden in the hearts. Treatment with BSO plus nifurtimox caused an increase in the survival rate in comparison to the rates with treatment with each drug alone.
摘要
以220毫克/千克体重/天的剂量给予L-丁硫氨酸（S，R）-亚砜亚胺（BSO）对感染克氏锥虫的小鼠显示出抗锥虫效果，提高了它们的存活率，并降低了心脏中的寄生虫血症和寄生虫负荷。与单独使用每种药物治疗的存活率相比，用BSO加硝呋莫司治疗使存活率有所提高。
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