Popescu Manuela, Dumitraşcu D L, Pascu O
"Iuliu Haţieganu" University of Medicine and Pharmacy, Third Medical Department, Cluj-Napoca, Romania.
Rom J Intern Med. 2007;45(3):259-62.
The Helicobacter pylori (Hp) infection is a well-known carcinogenic factor. There are only limited data on the presence of Hp infection in gastric cancer in Romania.
Cross-sectional study of the prevalence of Hp infection in gastric cancer.
MATERIAL-METHODS: All cases of gastric cancer confirmed by gastroscopy in an endoscopy unit with national referrals were analysed. The Hp status was checked. The Hp + cases were studied compared with the Hp - cases.
From 6768 gastroscopies 84 cases with gastric cancer were detected. Among these in 40 the Hp status was determined. 37 cases were carcinoma, 1 lymphoma, 2 cases without microscopical aspect of malignancy. In 8 cases (20%) Hp was found +. The majority of the patients with gastric cancer did not use PPIs. There were no demographic life style differences between the patients with gastric cancer who were Hp + and Hp -.
Prevalence of the Hp infection in gastric cancer is lower than that reported in the literature. The investigation of Hp in gastric cancer should be done routinely. These data represent the starting point for a prospective study.
幽门螺杆菌（Hp）感染是一种众所周知的致癌因素。关于罗马尼亚胃癌患者中Hp感染情况的数据有限。
对胃癌中Hp感染患病率进行横断面研究。
分析了一家接受全国转诊的内镜检查单位通过胃镜确诊的所有胃癌病例。检查了Hp状态。对Hp阳性病例与Hp阴性病例进行了研究比较。
在6768例胃镜检查中，检测出84例胃癌病例。其中40例确定了Hp状态。37例为癌，1例为淋巴瘤，2例无恶性微观表现。8例（20%）发现Hp阳性。大多数胃癌患者未使用质子泵抑制剂。Hp阳性和Hp阴性的胃癌患者在人口统计学生活方式上没有差异。
胃癌中Hp感染的患病率低于文献报道。应常规对胃癌患者进行Hp检测。这些数据是前瞻性研究的起点。
