Lichiardopol Corina, Moţa Maria
University of Medicine and Pharmacy, Craiova, Romania.
Rom J Intern Med. 2007;45(2):177-82.
Turner syndrome (TS) is characterized by an increased prevalence of hypothyroidism, the main etiology being autoimmunity. The aim of our study was to assess the prevalence of hypothyroidism in patients with Turner syndrome, to analyze the correlations with clinical, chromosomal, hormonal and metabolic features and to compare hypothyroid with euthyroid Turner subjects. We studied 28 patients with TS (mean age 24.68 +/- 9.59yr). 78.57% with 45,XO. 10.71% with 45,XO/46,XX and 10.71% with other karyotypes. Hypothyroidism was diagnosed in 10 patients (35.7%). TSH level was positively correlated with thyroid autoantibodies titer (p < 0.001), maternal age at conception (p< 0.01), the presence of spontaneous puberty (p < 0.05) and relative height (p < 0.05), and negatively correlated with FSH level (p < 0.001) which is an indicator of the estrogenic status, and was not correlated to karyotype. Hypothyroid Turner subjects had higher relative heights (p < 0.05) and lower FSH levels (p < 0.05) than euthyroid subjects, but cholesterol levels and BMI were not significantly different.
特纳综合征（TS）的特征是甲状腺功能减退的患病率增加，主要病因是自身免疫。我们研究的目的是评估特纳综合征患者甲状腺功能减退的患病率，分析其与临床、染色体、激素和代谢特征的相关性，并比较甲状腺功能减退的特纳综合征患者与甲状腺功能正常的患者。我们研究了28例特纳综合征患者（平均年龄24.68±9.59岁）。78.57%为45,XO，10.71%为45,XO/46,XX，10.71%为其他核型。10例患者（35.7%）被诊断为甲状腺功能减退。促甲状腺激素（TSH）水平与甲状腺自身抗体滴度呈正相关（p<0.001），与受孕时母亲年龄呈正相关（p<0.01），与自然青春期的存在呈正相关（p<0.05），与相对身高呈正相关（p<0.05），与作为雌激素状态指标的促卵泡生成素（FSH）水平呈负相关（p<0.001），且与核型无关。甲状腺功能减退的特纳综合征患者比甲状腺功能正常的患者相对身高更高（p<0.05），FSH水平更低（p<0.05），但胆固醇水平和体重指数无显著差异。
