病史与阿尔茨海默病风险：病例对照研究的协作性重新分析。欧洲痴呆症风险因素研究小组

Medical history and the risk of Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group.

作者信息

Breteler M M, van Duijn C M, Chandra V, Fratiglioni L, Graves A B, Heyman A, Jorm A F, Kokmen E, Kondo K, Mortimer J A

机构信息

Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.

出版信息

Int J Epidemiol. 1991;20 Suppl 2:S36-42. doi: 10.1093/ije/20.supplement_2.s36.

DOI:10.1093/ije/20.supplement_2.s36

PMID:1833352

Abstract

In a re-analysis of eight case-control studies on Alzheimer's disease we explored several medical conditions that had previously been suggested as possible risk factors for Alzheimer's disease. History of hypothyroidism was increased in cases as compared to controls (relative risk 2.3; 95% confidence interval 1.0-5.4). Severe headaches and migraine were inversely related to Alzheimer's disease (relative risk 0.7; 95% confidence interval 0.5-1.0). More cases than controls reported epilepsy before onset of Alzheimer's disease (relative risk 1.6; 95% confidence interval 0.7-3.5), especially for epilepsy with an onset within 10 years of onset of dementia. Neurotropic viruses, allergic conditions, general anaesthesia and blood transfusions were not associated with Alzheimer's disease.

摘要

在对八项关于阿尔茨海默病的病例对照研究进行重新分析时，我们探究了几种先前被认为可能是阿尔茨海默病风险因素的医学状况。与对照组相比，病例组甲状腺功能减退病史有所增加（相对风险2.3；95%置信区间1.0 - 5.4）。严重头痛和偏头痛与阿尔茨海默病呈负相关（相对风险0.7；95%置信区间0.5 - 1.0）。在阿尔茨海默病发病前，报告有癫痫的病例多于对照组（相对风险1.6；95%置信区间0.7 - 3.5），尤其是在痴呆发病10年内发病的癫痫。嗜神经病毒、过敏状况、全身麻醉和输血与阿尔茨海默病无关。