Uharcek P, Mlyncek M, Ravinger J, Matejka M
Department of Obstetrics and Gynecology, Faculty Hospital Nitra, Nitra, Slovakia.
Int J Gynecol Cancer. 2008 Mar-Apr;18(2):324-8. doi: 10.1111/j.1525-1438.2007.00997.x.
The purpose of this study was to conduct a clinical and pathologic review of endometrial cancers diagnosed in women aged younger than 45 years to better identify the prognostic factors for this subgroup of women. We retrospectively evaluated the clinical history, treatment, and follow-up of patients with histologically confirmed endometrial cancer treated in Faculty Hospital Nitra, Slovakia from 1993 to 2003. Data were abstracted regarding tumor histology, grade, age, parity, stage, diabetes, use of oral contraceptives, body mass index (BMI), and survival. One hundred seventy-three patients with endometrioid histology were divided into two groups: younger group (age <or=45 years, n = 20) and older group (age >45, n = 153). Patients with high-risk histology (clear cell or serous papillary) were excluded from the study. Twenty patients less than or equal to 45 years of age received treatment for endometrial cancer: stage I, 16 (80%); stage II, 2 (10%); stage III, 1 (5%); and stage IV, 1 (5%). Tumors were well differentiated in 12 (60%), moderately differentiated in 6 (30%), and poorly differentiated in 2 (10%). Age ranged from 28 to 45 years (mean 37), with mean BMI 35.8 +/- 9.4. At the end of study period, 17 (85%) were alive with no evidence of disease and 3 (15%) had died of recurrent disease. We conclude that patients less than or equal to 45 years of age have better survival compared to older patients. Deeper myometrial invasion was significantly associated with age greater than 45 years. Majority of young patients with endometrial cancer were obese and nulliparous.
本研究的目的是对45岁以下女性诊断出的子宫内膜癌进行临床和病理回顾，以更好地确定该亚组女性的预后因素。我们回顾性评估了1993年至2003年在斯洛伐克尼特拉市大学医院接受治疗的组织学确诊子宫内膜癌患者的临床病史、治疗及随访情况。提取了有关肿瘤组织学、分级、年龄、产次、分期、糖尿病、口服避孕药使用情况、体重指数（BMI）及生存情况的数据。173例子宫内膜样组织学患者被分为两组：年轻组（年龄≤45岁，n = 20）和老年组（年龄>45岁，n = 153）。高危组织学类型（透明细胞或浆液性乳头状）的患者被排除在研究之外。20例年龄小于或等于45岁的患者接受了子宫内膜癌治疗：I期，16例（80%）；II期，2例（10%）；III期，1例（5%）；IV期，1例（5%）。肿瘤高分化12例（60%），中分化6例（30%），低分化2例（10%）。年龄范围为28至45岁（平均37岁），平均BMI为35.8±9.4。在研究期结束时，17例（85%）存活且无疾病证据，3例（15%）死于复发性疾病。我们得出结论，年龄小于或等于45岁的患者与老年患者相比生存情况更好。肌层浸润深度与年龄大于45岁显著相关。大多数年轻的子宫内膜癌患者肥胖且未生育。
