血浆黏度，亚临床甲状腺功能减退女性的早期心血管危险因素。
Plasma viscosity, an early cardiovascular risk factor in women with subclinical hypothyroidism.
作者信息
Erdem T Y, Ercan M, Ugurlu S, Balci H, Acbay O, Gundogdu S
机构信息
Department of Endocrinology and Metabolism, Istanbul University, Cerrahpasa Medical Faculty, Turkey.
出版信息
Clin Hemorheol Microcirc. 2008;38(4):219-25.
OBJECTIVE
It is controversial, if subclinical hypothyroidism increases cardiovascular risk. Plasma viscosity is a hemorheological parameter, which is accepted as an early cardiovascular risk factor. We investigated the alterations in plasma viscosity in women with subclinical hypothyroidism.
DESIGN
40 female patients with subclinical hypothyroidism and 31 age- and weight-matched healthy women were included. Free thyroxine (FT4), thyroid stimulating hormone (TSH), lipid parameters, fibrinogen, C-reactive protein (CRP) levels, hematocrit and plasma viscosity were measured in all subjects.
MAIN OUTCOME
Plasma viscosity, total cholesterol and low density lipoprotein were significantly increased and high density lipoprotein was significantly decreased in patients with subclinical hypothyroidism. No significant correlation was found among the parameters.
CONCLUSION
Increased plasma viscosity in patients' group suggests that cardiovascular risk might be increased in patients with subclinical hypothyroidism. As far as we could reach, this is the first study concerning plasma viscosity in subclinical hypothyroidism.
目的
亚临床甲状腺功能减退是否会增加心血管疾病风险存在争议。血浆黏度是一种血液流变学参数，被认为是早期心血管危险因素。我们研究了亚临床甲状腺功能减退女性的血浆黏度变化。
设计
纳入40例亚临床甲状腺功能减退女性患者以及31例年龄和体重匹配的健康女性。测定所有受试者的游离甲状腺素（FT4）、促甲状腺激素（TSH）、血脂参数、纤维蛋白原、C反应蛋白（CRP）水平、血细胞比容和血浆黏度。
主要结果
亚临床甲状腺功能减退患者的血浆黏度、总胆固醇和低密度脂蛋白显著升高，高密度脂蛋白显著降低。各参数之间未发现显著相关性。
结论
患者组血浆黏度升高表明亚临床甲状腺功能减退患者的心血管疾病风险可能增加。就我们所知，这是第一项关于亚临床甲状腺功能减退患者血浆黏度的研究。
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