Nejat Farideh, Yazdani Shahrooz, El Khashab Mostafa
Department of Neurosurgery, Children's Hospital Medical Center, Medical Sciences, University of Tehran, Tehran, Iran.
Pediatr Neurosurg. 2008;44(3):190-2. doi: 10.1159/000120148. Epub 2008 Mar 11.
The setting sun eye is a common sign associated with severe disorders signifying intracranial hypertension. Rarely it can be observed in a healthy infant. We conducted this study to evaluate and follow setting sun eye in normal infants without any obvious intracranial diseases.
A cross-sectional study was conducted in the Children's Hospital Medical Center in Tehran from June 2001 to 2006. The study included 15 healthy infants who were referred to the neurosurgery clinic for setting sun eye. All were evaluated with brain imaging, and laboratory tests including at least thyroid function tests, and serum calcium and phosphorus. The cases were followed by regular outpatient visits until the age of 2 years.
They were 3-8 months old at the time of referring to the outpatient clinic. Setting sun eye was observed by the mother in all cases and confirmed during their visit to the clinic. All had normal brain imaging and normal laboratory tests (thyroid function and electrolytes). Setting sun eye disappeared gradually during the follow-up period with a range of 2-8 months after detection by the mother.
Despite the fact that setting sun eye is a grave sign, most commonly accompanied by other neurological signs and symptoms suggesting serious diseases, it might be observed as a sole finding in a totally normal infant with inconclusive brain imaging and laboratory tests. We found that this type of setting sun eye has a benign course and will disappear without any intervention several months after its detection (commonly before the age of 2 years without any intervention).
落日眼是与严重疾病相关的常见体征，提示颅内高压。在健康婴儿中很少见。我们开展这项研究以评估和随访无明显颅内疾病的正常婴儿中的落日眼。
2001年6月至2006年在德黑兰儿童医院医学中心进行了一项横断面研究。该研究纳入了15名因落日眼转诊至神经外科门诊的健康婴儿。所有婴儿均接受了脑成像检查以及实验室检查，包括至少甲状腺功能检查、血清钙和磷检查。对这些病例进行定期门诊随访直至2岁。
他们在转诊至门诊时年龄为3至8个月。所有病例的母亲均观察到落日眼，在其就诊时得到确认。所有婴儿脑成像和实验室检查（甲状腺功能和电解质）均正常。在随访期间，落日眼在母亲发现后的2至8个月内逐渐消失。
尽管落日眼是一个严重的体征，最常伴有提示严重疾病的其他神经体征和症状，但在脑成像和实验室检查无定论的完全正常婴儿中，它可能是唯一发现。我们发现这种类型的落日眼病程良性，在发现后数月（通常在2岁前无需任何干预）会自行消失。
