Pérez-Nuñez A, Lagares A, Pascual B, Rivas J J, Alday R, González P, Cabrera A, Lobato R D
Servicio de Neurocirugía, Hospital Universitario Doce de Octubre, Madrid.
Neurocirugia (Astur). 2008 Feb;19(1):12-24.
Spontaneous intracerebral haematoma (SICH) represents one the most severe subtypes of ictus. However, and despite a high incidence, medical treatment is almost limited to life support and to control intracranial hypertension and indications of surgical treatment are poorly defined. The aim of this paper was to review the evidence supporting surgical evacuation of SICH. Ten clinical trials and five meta-analyses studying the results of surgical treatment on this pathology were found on English literature. These studies considered all together, failed to show a significant benefit of surgical evacuation in patients with SICH considered as a whole. However, a subgroup of these patients has been considered to potentially present a better outcome after surgical treatment. Current recommendations on supratentorial intra-cerebral haemorrhage state that young patients with lobar haematomas causing deterioration on the level of consciousness should be operated on. Patients suffering from putaminal haematomas and fitting with the same criteria of age and neurological deterioration could also benefit from surgery, at least on terms of survival. Deep neurological deterioration with GCS<5, thalamic location, severe functional deterioration on basal condition or advanced age precluding an adequate functional outcome, have been traditionally considered criteria contraindicating surgery. Given the absence of strong scientific evidence to indicate surgery, this measure should be taken on a tailored manner, and taking into account the social-familiar environment of the patient, that will strongly condition his/her future quality of life.
自发性脑出血(SICH)是卒中最严重的亚型之一。然而,尽管发病率很高,但药物治疗几乎仅限于生命支持以及控制颅内高压,手术治疗的指征也尚不明确。本文旨在综述支持SICH手术清除血肿的证据。在英文文献中发现了10项关于该病理状况手术治疗结果的临床试验和5项荟萃分析。综合来看,这些研究未能表明对整体的SICH患者进行手术清除血肿有显著益处。然而,这些患者中的一个亚组被认为可能在手术治疗后有更好的预后。目前关于幕上脑出血的建议指出,年轻的脑叶血肿患者若出现意识水平恶化应进行手术。患有壳核血肿且符合相同年龄和神经功能恶化标准的患者也可能从手术中获益,至少在生存方面。传统上,格拉斯哥昏迷量表(GCS)评分<5的深度神经功能恶化、丘脑部位出血、基础状态下严重功能恶化或因年龄较大而无法获得良好功能结局等情况被视为手术禁忌证。鉴于缺乏强有力的科学证据表明手术的必要性,应根据患者的具体情况,并考虑其社会家庭环境(这将对其未来生活质量产生重大影响),量身定制手术方案。