Akbari E M, Budin R, Parada M, Fleming A S
Department of Psychology, University of Toronto at Mississauga, Mississauga, ON Canada L5L 1C6.
Dev Psychobiol. 2008 Apr;50(3):298-306. doi: 10.1002/dev.20290.
Previous findings have demonstrated that the maternal environment is important for the development of male sexual behavior. The present study examined the effects of complete early life isolation and replacement 'stroking' stimulation on male sexual behavior and neural activation as seen by Fos immunoreactivity (Fos-IR). Animals were either artificially reared (AR) with minimal (AR-MIN) or maximal (AR-MAX) body simulation, or maternally reared (MR). In adulthood, animals were either given an exposure to an estrous female (EXP) or left undisturbed (NoEXP). No significant effects of early development were found in sexual behavior; however differences in activation in response to this exposure were observed. AR-MIN animals showed lower Fos-IR in the medial preoptic area and the ventromedial hypothalamus compared to MR animals. AR-MAX animals were not significantly different from either condition. These findings demonstrate that although there are no differences in the quality of the first copulatory exposure between AR and MR animals, the brain's response to this exposure differs in sites within the brain that subserve sexual behavior.
先前的研究结果表明，母体环境对雄性性行为的发育很重要。本研究通过Fos免疫反应性（Fos-IR）检测了早期完全隔离和替代“抚摸”刺激对雄性性行为和神经激活的影响。动物要么在极少（AR-MIN）或极多（AR-MAX）身体刺激的情况下人工饲养（AR），要么由母体抚养（MR）。成年后，动物要么接触处于发情期的雌性（EXP），要么不受干扰（NoEXP）。在性行为方面未发现早期发育的显著影响；然而，观察到对这种接触的激活存在差异。与MR动物相比，AR-MIN动物在内侧视前区和腹内侧下丘脑显示出较低的Fos-IR。AR-MAX动物与这两种情况均无显著差异。这些发现表明，尽管AR和MR动物首次交配接触的质量没有差异，但大脑对这种接触的反应在参与性行为的脑区有所不同。
