纳米水相胶束中室温下的赫克偶联反应。

Heck couplings at room temperature in nanometer aqueous micelles.

作者信息

Lipshutz Bruce H, Taft Benjamin R

机构信息

Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, USA.

出版信息

Org Lett. 2008 Apr 3;10(7):1329-32. doi: 10.1021/ol702755g. Epub 2008 Mar 12.

DOI:10.1021/ol702755g

PMID:18335945

Abstract

A nonionic amphiphile such as Triton X-100 or the vitamin E-based PTS, both of which form nanomicelles in water, promotes Heck cross-couplings of non-water-soluble partners at ambient temperatures. These are the first examples of Heck reactions conducted in water (as the only solvent) at room temperature.

摘要

非离子两亲物，如聚乙二醇辛基苯基醚（Triton X-100）或基于维生素E的PTS，二者均可在水中形成纳米胶束，能在环境温度下促进非水溶性反应物之间的Heck交叉偶联反应。这些是在室温下于水（作为唯一溶剂）中进行的Heck反应的首例。