2,4-二卤代恶唑的区域选择性钯交叉偶联反应：三恶唑的汇聚合成
Regioselective palladium cross-coupling of 2,4-dihalooxazoles: convergent synthesis of trisoxazoles.
作者信息
Flegeau Emmanuel Ferrer, Popkin Matthew E, Greaney Michael F
机构信息
School of Chemistry, University of Edinburgh, Joseph Black Building, King's Buildings, West Mains Road, Edinburgh EH9 3JJ, UK.
出版信息
J Org Chem. 2008 Apr 18;73(8):3303-6. doi: 10.1021/jo800121y. Epub 2008 Mar 12.
PMID:18335963
Abstract
A regioselective Suzuki-Miyaura cross-coupling of 2,4-dihalooxazoles followed by a Stille coupling has been successfully developed. The procedure affords convergent syntheses of trisoxazoles in high yield and in a minimum number of steps.
摘要
已成功开发出一种2,4-二卤代恶唑的区域选择性铃木-宫浦交叉偶联反应，随后进行施蒂勒偶联反应。该方法能以高产率和最少的步骤实现三恶唑的汇聚合成。
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