Abd El-Latif Nehad A, Abdulla Mohamed M, Amr Abd El-Galil E
Natural Compounds Department, National Research Center, Cairo Dokki, Egypt.
Acta Pharm. 2008 Mar;58(1):43-59. doi: 10.2478/v10007-007-0044-2.
In this study, we synthesized some new substituted steroidal derivatives using 3beta-hydroxyandrosten-17-one (dehydroepiandrosterone) as starting material. The synthesized steroidal derivatives 1-11 were evaluated for their androgenic-anabolic activities compared to testosterone as positive control. Details of the synthesis, spectroscopic data and toxicity (LD50) of synthesized compounds are reported.
在本研究中,我们以3β-羟基雄甾-17-酮(脱氢表雄酮)为起始原料合成了一些新的取代甾体衍生物。将合成的甾体衍生物1-11与作为阳性对照的睾酮相比,评估它们的雄激素-同化活性。报告了合成化合物的合成细节、光谱数据和毒性(半数致死量)。