以3β-羟基雄甾-17-酮为起始原料合成的新型甾体衍生物。
New steroidal derivatives synthesized using 3beta-hydroxyandrosten-17-one as starting material.
作者信息
Abd El-Latif Nehad A, Abdulla Mohamed M, Amr Abd El-Galil E
机构信息
Natural Compounds Department, National Research Center, Cairo Dokki, Egypt.
出版信息
Acta Pharm. 2008 Mar;58(1):43-59. doi: 10.2478/v10007-007-0044-2.
PMID:18337207
Abstract
In this study, we synthesized some new substituted steroidal derivatives using 3beta-hydroxyandrosten-17-one (dehydroepiandrosterone) as starting material. The synthesized steroidal derivatives 1-11 were evaluated for their androgenic-anabolic activities compared to testosterone as positive control. Details of the synthesis, spectroscopic data and toxicity (LD50) of synthesized compounds are reported.
摘要
在本研究中，我们以3β-羟基雄甾-17-酮（脱氢表雄酮）为起始原料合成了一些新的取代甾体衍生物。将合成的甾体衍生物1-11与作为阳性对照的睾酮相比，评估它们的雄激素-同化活性。报告了合成化合物的合成细节、光谱数据和毒性（半数致死量）。
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