Chan Alexandre, Shih Vivianne, Chew Lita
Department of Pharmacy, National University of Singapore, Singapore.
J Oncol Pharm Pract. 2008 Mar;14(1):23-9. doi: 10.1177/1078155207084009.
National Cancer Centre (NCC) is currently the largest ambulatory oncology treatment centre in Singapore that treats mainly solid tumors and lymphomas. Oncology pharmacists at NCC play an active role in the management of CINV. In order to improve the clinical services delivered by pharmacy, particularly in the utilization of antiemetics, pharmacy department conducted a survey that aimed to understand the prescribing patterns of antiemetics for CINV.
ves. The primary aim of this study was to describe medical oncologists' perceptions of factors that can influence prescribing of antiemetics for acute and delayed nausea and vomiting associated with chemotherapy. A secondary aim was to assess medical oncologists' perception of antiemetic counseling by oncology pharmacists.
This was a single-centered, non-randomized survey conducted at NCC in Singapore. Twenty-seven oncologists in the Department of Medical Oncology (DMO) were invited to participate in this survey. Survey forms were distributed to the medical oncologists at weekly DMO and tumor board meetings in November 2006.
Twenty oncologists returned surveys during the study period. Most oncologists closely adhered to the institution guideline on antiemetics utilization; however, results showed a trend of overprescribing acute antiemetics for low emetogenic chemotherapy regimens. Oncologists have identified anxiety, age and gender as the top three patient risk factors taken into consideration when they prescribe antiemetics. Majority of oncologists found pharmacists' counseling on antiemetics to be effective.
Through this survey, oncology pharmacists at NCC were able to identify areas of antiemetics utilization that needed refinement. Results from this survey provide opportunities for oncology pharmacists to collaborate with medical oncologists to further improve the management of chemotherapy induced nausea and vomiting.
新加坡国立癌症中心（NCC）是目前该国最大的门诊肿瘤治疗中心，主要治疗实体瘤和淋巴瘤。NCC的肿瘤药剂师在化疗所致恶心呕吐（CINV）的管理中发挥着积极作用。为了改善药学部门提供的临床服务，尤其是在止吐药的使用方面，药学部门开展了一项调查，旨在了解CINV止吐药的处方模式。
本研究的主要目的是描述肿瘤内科医生对可能影响与化疗相关的急性和延迟性恶心呕吐的止吐药处方因素的看法。次要目的是评估肿瘤内科医生对肿瘤药剂师进行的止吐药咨询的看法。
这是在新加坡NCC进行的一项单中心、非随机调查。邀请了肿瘤内科（DMO）的27位肿瘤内科医生参与这项调查。2006年11月，在每周的DMO和肿瘤病例讨论会上向肿瘤内科医生分发调查问卷。
在研究期间，20位肿瘤内科医生返还了调查问卷。大多数肿瘤内科医生严格遵守机构关于止吐药使用的指南；然而，结果显示对于低致吐性化疗方案存在过度开具急性止吐药的趋势。肿瘤内科医生已将焦虑、年龄和性别确定为他们在开具止吐药时考虑的前三大患者风险因素。大多数肿瘤内科医生认为药剂师关于止吐药的咨询是有效的。
通过这项调查，NCC的肿瘤药剂师能够确定止吐药使用中需要改进的方面。这项调查的结果为肿瘤药剂师与肿瘤内科医生合作进一步改善化疗所致恶心呕吐的管理提供了机会。
