识别HLA - A2和甲型流感病毒基质肽的人类T细胞抗原受体α链和β链的广泛保守性
Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide.
作者信息
Moss P A, Moots R J, Rosenberg W M, Rowland-Jones S J, Bodmer H C, McMichael A J, Bell J I
机构信息
Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom.
出版信息
Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8987-90. doi: 10.1073/pnas.88.20.8987.
Abstract
The major histocompatibility complex class I molecule HLA-A2.1 presents the influenza A virus matrix peptide 57-68 to cytotoxic T lymphocytes in all individuals with this common HLA type and is among the most thoroughly studied immune responses in humans. We have studied the T-cell receptor (TCR) heterogeneity of T cells specific for HLA-A2 and influenza A matrix peptide using the polymerase chain reaction. The usage of V alpha and V beta sequences seen on these T cells is remarkably conserved as are certain junctional sequences associated with alpha and beta chains. Furthermore, two unrelated HLA-A2 individuals have a similar pattern of TCR usage, implying that this is a predominant response in HLA-A2 populations. Analysis in one individual showed that the conserved TCR V alpha and V beta genes are minor members of the peripheral blood TCR repertoire. The sequences provide important information on the TCR necessary for the final structural analysis of this ternary complex.
摘要
主要组织相容性复合体I类分子HLA - A2.1在所有具有这种常见HLA类型的个体中，将甲型流感病毒基质肽57 - 68呈递给细胞毒性T淋巴细胞，并且是人类中研究最为深入的免疫反应之一。我们使用聚合酶链反应研究了针对HLA - A2和甲型流感病毒基质肽的T细胞的T细胞受体（TCR）异质性。这些T细胞上可见的Vα和Vβ序列的使用情况以及与α和β链相关的某些连接序列都非常保守。此外，两名无关的HLA - A2个体具有相似的TCR使用模式，这意味着这是HLA - A2群体中的主要反应。对一名个体的分析表明，保守的TCR Vα和Vβ基因是外周血TCR库中的少数成员。这些序列为该三元复合物的最终结构分析所需的TCR提供了重要信息。
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本文引用的文献
1
Sequences and repertoire of the human T cell receptor alpha and beta chain variable region genes in thymocytes.胸腺细胞中人T细胞受体α和β链可变区基因的序列及谱系
Eur J Immunol. 1987 Mar;17(3):375-83. doi: 10.1002/eji.1830170312.
2
Dominance of one T-cell receptor in the H-2Kb/TNP response.在H-2Kb/TNP反应中一种T细胞受体的优势地位。
Nature. 1987;326(6110):307-9. doi: 10.1038/326307a0.
3
Structure of the human class I histocompatibility antigen, HLA-A2.人类I类组织相容性抗原HLA - A2的结构
Nature. 1987;329(6139):506-12. doi: 10.1038/329506a0.
4
Recognition of influenza A matrix protein by HLA-A2-restricted cytotoxic T lymphocytes. Use of analogues to orientate the matrix peptide in the HLA-A2 binding site.HLA-A2 限制性细胞毒性 T 淋巴细胞对甲型流感病毒基质蛋白的识别。使用类似物确定基质肽在 HLA-A2 结合位点中的方向。
J Exp Med. 1988 Dec 1;168(6):2045-57. doi: 10.1084/jem.168.6.2045.
5
Sequences and repertoire of human T cell receptor alpha chain variable region genes in mature T lymphocytes.成熟T淋巴细胞中人T细胞受体α链可变区基因的序列与库
J Exp Med. 1986 Jul 1;164(1):90-103. doi: 10.1084/jem.164.1.90.
6
T-cell antigen receptor genes and T-cell recognition.T细胞抗原受体基因与T细胞识别
Nature. 1988 Aug 4;334(6181):395-402. doi: 10.1038/334395a0.
7
Correlations between T-cell specificity and the structure of the antigen receptor.T细胞特异性与抗原受体结构之间的相关性。
Nature. 1986;321(6067):219-26. doi: 10.1038/321219a0.
8
Molecular genetic analysis of 178 I-Abm12-reactive T cells.178个I-Abm12反应性T细胞的分子遗传学分析。
J Exp Med. 1989 Jan 1;169(1):115-33. doi: 10.1084/jem.169.1.115.
9
10
Effect of mutations and variations of HLA-A2 on recognition of a virus peptide epitope by cytotoxic T lymphocytes.HLA - A2的突变和变异对细胞毒性T淋巴细胞识别病毒肽表位的影响。
Proc Natl Acad Sci U S A. 1988 Dec;85(23):9194-8. doi: 10.1073/pnas.85.23.9194.
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