Leary W P, Maharaj B, Van der Byl K
Department of Clinical and Experimental Pharmacology, University of Natal, Durban.
S Afr Med J. 1991 Oct 5;80(7):322-3.
Male patients with supine diastolic blood pressures above 95 mmHg after placebo therapy received twice daily isradipine (Dynacirc; Sandoz) 1.25, 2.5 or 5.0 mg for 12 weeks. Blood pressures were measured every 14 days. Doses of 2.5 or 5 mg isradipine twice daily significantly reduced supine and erect mean systolic, mean diastolic and mean arterial pressures. Isradipine 1.25 mg twice daily reduced supine mean diastolic and mean arterial pressures only. A dose of 5 mg twice daily was accompanied by an increase in adverse reactions. The recommended dose of isradipine is 2.5 mg twice daily.
安慰剂治疗后仰卧位舒张压高于95 mmHg的男性患者，每日两次服用1.25、2.5或5.0 mg伊拉地平（达罗地平；山德士公司），持续12周。每14天测量一次血压。每日两次服用2.5或5 mg伊拉地平可显著降低仰卧位和直立位的平均收缩压、平均舒张压和平均动脉压。每日两次服用1.25 mg伊拉地平仅降低仰卧位平均舒张压和平均动脉压。每日两次服用5 mg伊拉地平会伴随不良反应增加。伊拉地平的推荐剂量为每日两次2.5 mg。
