Mignogna Chiara, Simonetti Sara, Galloro Giuseppe, Magno Luca, De Cecio Rossella, Insabato Luigi
Department of Biomorphological and Functional Sciences, Pathology Section, University of Naples Federico II, Naples, Italy.
Tumori. 2007 Nov-Dec;93(6):619-21. doi: 10.1177/030089160709300619.
Angiosarcomas are uncommon malignant tumors of vascular endothelium that represent less than 1% of all sarcomas. The epithelioid variant of angiosarcomas is exceptionally rare, and the gastrointestinal tract is rarely involved. Angiosarcomas mainly involve skin and soft tissue and rarely occur in breast, liver, bone, and spleen. We present the case of a 30-year-old man who underwent an upper gastrointestinal endoscopy for melena. A duodenal reddish polypoid lesion was found, which on microscopic examination turned out to be an epithelioid angiosarcoma. The immunohistochemical features of the lesion supported this diagnosis. The patient died eight months after the diagnosis. Epithelioid angiosarcoma is an aggressive variant of angiosarcoma and must be considered in the differential diagnosis of gastrointestinal tumors.
血管肉瘤是一种罕见的血管内皮恶性肿瘤，占所有肉瘤的比例不到1%。血管肉瘤的上皮样变体极为罕见，胃肠道很少受累。血管肉瘤主要累及皮肤和软组织，很少发生于乳腺、肝脏、骨骼和脾脏。我们报告一例30岁男性因黑便接受上消化道内镜检查的病例。发现十二指肠有一个红色息肉样病变，经显微镜检查证实为上皮样血管肉瘤。病变的免疫组化特征支持这一诊断。患者在诊断后八个月死亡。上皮样血管肉瘤是血管肉瘤的一种侵袭性变体，在胃肠道肿瘤的鉴别诊断中必须予以考虑。
