Saad Ali G, Jayarao Mayur, Chin Lawrence S, Delalle Ivana
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Pediatr Dev Pathol. 2008 Nov-Dec;11(6):474-8. doi: 10.2350/07-10-0360.1. Epub 2008 Feb 25.
Ganglioglioma is a tumor occurring in children and young adults and characterized by a superficial cortical location and biphasic histologic differentiation encompassing neuronal and glial elements. Ganglioglioma may arise anywhere throughout the neuraxis, including the optic nerve, brain stem, pineal gland, cerebellum, cerebrum, and spinal cord; however, the majority of glioneuronal neoplasms involve the temporal lobe. Gangliogliomas may show focal leptomeningeal involvement, but predominant leptomeningeal involvement by gangliogliomas is extremely rare; only 2 cases of ganglioglioma extensively involving the leptomeninges have been reported. In this report, we present an unusual case of a ganglioglioma predominantly present within the leptomeninges of a 15-year-old boy with a history of seizures. Furthermore, the cerebral cortex beneath the tumor showed dysplastic changes. We report a very unusual case of ganglioglioma involving predominantly the cerebral leptomeninges and associated with adjacent cerebral cortical dysplasia. Histologic characteristics and diagnostic pitfalls are discussed.
节细胞胶质瘤是一种发生于儿童和年轻人的肿瘤，其特征为位于浅表皮质，具有包括神经元和胶质成分的双相组织学分化。节细胞胶质瘤可发生于整个神经轴的任何部位，包括视神经、脑干、松果体、小脑、大脑和脊髓；然而，大多数神经胶质神经元肿瘤累及颞叶。节细胞胶质瘤可表现为局灶性软脑膜受累，但节细胞胶质瘤以软脑膜受累为主极为罕见；仅报道过2例节细胞胶质瘤广泛累及软脑膜的病例。在本报告中，我们介绍了1例不寻常的节细胞胶质瘤病例，主要位于一名有癫痫病史的15岁男孩的软脑膜内。此外，肿瘤下方的大脑皮质显示发育异常改变。我们报告了1例非常不寻常的节细胞胶质瘤病例，主要累及大脑软脑膜并伴有相邻大脑皮质发育异常。讨论了组织学特征和诊断陷阱。
