Baron J J
Endokrinologische Klinik des Instituts für Gynäkologie und Geburtshilfe, Poznań.
Zentralbl Gynakol. 1991;113(9):511-7.
One hundred and fourteen nontumorous hirsute women were investigated. The degree of hirsutism, the menstrual abnormalities and the level of 17-ketosteroids, of DHEA, of 17-OH-corticoids in urine and RIA of total and free testosterone and of sex binding globulins (SHBG) in blood were performed. On the basis of endocrinological and ultrasonographic determinations 3 patients were diagnosed as congenital adrenal hyperplasia, 35 patients as late onset adrenal hyperplasia and 57 women as polycystic ovary syndrome (PCO). The maximal mean level (X + SD) of total and free testosterone above 0.5 ng/ml relatively above 5.05 pg/ml were performed in 94.3% relatively 97.1% in late onset adrenal hyperplasia and in 78.9% relatively 87.7% in PCO. The diagnosis of PCO is possible among 75% of all hirsute patients after exclusion the patients with late onset adrenal hyperplasia. The PCO is confirmed by hormonal or/and ultrasonographic examination. The diagnosis of late onset adrenal hyperplasia is allowable only by hormonal investigation.
对114例非肿瘤性多毛女性进行了研究。检测了多毛程度、月经异常情况以及尿中17 - 酮类固醇、脱氢表雄酮、17 - 羟皮质类固醇水平,以及血液中总睾酮、游离睾酮和性结合球蛋白(SHBG)的放射免疫分析。根据内分泌学和超声检查结果,3例患者被诊断为先天性肾上腺皮质增生症,35例为迟发性肾上腺皮质增生症,57例女性为多囊卵巢综合征(PCO)。迟发性肾上腺皮质增生症患者中,总睾酮和游离睾酮的最大平均水平(X + SD)高于0.5 ng/ml(相对高于5.05 pg/ml)的比例分别为94.3%和97.1%;PCO患者中这一比例分别为78.9%和87.7%。排除迟发性肾上腺皮质增生症患者后,75%的多毛患者有可能诊断为PCO。PCO通过激素或/和超声检查确诊。迟发性肾上腺皮质增生症仅通过激素检查确诊。