三价灭活流感疫苗接种者中抗体与T细胞反应的不一致性。
Discordance between antibody and T cell responses in recipients of trivalent inactivated influenza vaccine.
作者信息
Co Mary Dawn T, Orphin Laura, Cruz John, Pazoles Pamela, Rothman Alan L, Ennis Francis A, Terajima Masanori
机构信息
Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, United States.
出版信息
Vaccine. 2008 Apr 7;26(16):1990-8. doi: 10.1016/j.vaccine.2008.02.024. Epub 2008 Feb 26.
Abstract
Thirty adults were tested for humoral and cellular immune responses following immunization with the trivalent inactivated influenza vaccine. Modest but significant inverse correlations between the baseline and the fold changes in the number of IFNgamma-producing cells and the levels of neutralizing antibodies were observed. Specific increases in proliferative responses in the CD8 CD45RA+ population were noted after vaccination. Minimal correlations between neutralizing antibody titers and the number of IFNgamma-producing cells in terms of prevaccination levels or fold increases were observed. These results show specific increases in a CD8 T cell subset and discordant T and B responses induced by the trivalent inactivated influenza vaccine.
摘要
对30名成年人接种三价灭活流感疫苗后进行体液免疫和细胞免疫反应检测。观察到产生IFNγ的细胞数量的基线与倍数变化以及中和抗体水平之间存在适度但显著的负相关。接种疫苗后，CD8 CD45RA+群体的增殖反应有特异性增加。在接种前水平或增加倍数方面，观察到中和抗体滴度与产生IFNγ的细胞数量之间的相关性极小。这些结果表明，三价灭活流感疫苗可使CD8 T细胞亚群特异性增加，并诱导T和B反应不一致。
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