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[慢性阻塞性肺疾病非重度加重患者咨询的概况与管理(Pragma调查)]

[Profile and management of patients consulting for a non severe exacerbation of chronic obstructive pulmonary disease (Pragma survey)].

作者信息

Léophonte P, Zuck P, Perronne C

机构信息

Clinique des voies respiratoires, hôpital Larrey, 24, chemin de Pouvouville, TSA 30030-31059 Toulouse cedex 09, France.

出版信息

Med Mal Infect. 2008 Apr;38(4):200-7. doi: 10.1016/j.medmal.2008.01.006. Epub 2008 Mar 12.

DOI:10.1016/j.medmal.2008.01.006
PMID:18339501
Abstract

OBJECTIVES

To evaluate, in patients with chronic obstructive pulmonary disease (COPD), stage 0 or 1, the percentage of patients who had spirometry, and to study their sociodemographic, clinical and epidemiological characteristics.

PATIENTS AND METHODS

An epidemiological survey was conducted with 2389 general practitioners concerning 4769 patients with early COPD, consulting for the first time for exacerbation of COPD, presumed to be bacterial.

RESULTS

Spirometry under stable conditions was performed in only 30% of patients. When the physician does not have access to this examination to guide antibiotic prescription for an exacerbation presumed to be bacterial, recent guidelines have established a correlation between dyspnoea and the degree of severity of COPD (GOLD classification). This correlation was not confirmed by the present study: 34% of patients with stage 0 or 1 COPD complained of dyspnoea and 52% of patients with stage 2 or 3 COPD did not complain of dyspnoea. The main criterion in favour of a bacterial cause of exacerbation, frank purulent sputum, observed in one out of three patients, did not influence the decision to prescribe antibiotics, given to 98% of patients. Therapy used bronchodilators (73%), even in patients with no signs of obstruction, and inhaled steroids (72%), although, according to guidelines, they are only indicated in the most serious forms (stage 3). This survey illustrates the effort needed to ensure better concordance between guidelines and practice, by taking into account the difficulties encountered by practitioners.

摘要

目的

评估0或1期慢性阻塞性肺疾病(COPD)患者中进行肺量计检查的患者百分比,并研究其社会人口学、临床和流行病学特征。

患者与方法

对2389名全科医生进行了一项流行病学调查,涉及4769例早期COPD患者,这些患者因疑似细菌性COPD加重首次就诊。

结果

仅30%的患者在稳定状态下进行了肺量计检查。当医生无法通过此项检查来指导针对疑似细菌性加重的抗生素处方时,近期指南已确立了呼吸困难与COPD严重程度(GOLD分级)之间的相关性。本研究未证实这种相关性:0或1期COPD患者中有34%主诉呼吸困难,而2或3期COPD患者中有52%未主诉呼吸困难。支持加重由细菌引起的主要标准,即三分之一患者中观察到的明显脓性痰,并未影响抗生素处方的决定,98%的患者都使用了抗生素。治疗使用了支气管扩张剂(73%),即使是在无阻塞迹象的患者中,还使用了吸入性类固醇(72%),尽管根据指南,它们仅适用于最严重的类型(3期)。这项调查说明了通过考虑从业者遇到的困难来确保指南与实践更好地一致所需做出的努力。

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