Weil Cliff, Martienssen Rob
Department of Agronomy, Purdue University, West Lafayette, IN, United States.
Curr Opin Genet Dev. 2008 Apr;18(2):188-92. doi: 10.1016/j.gde.2008.01.015. Epub 2008 Mar 12.
Transposons replicate, increase in copy number and persist in nature by moving, but insertion into genes is generally mutagenic. There is thus a strong selection for transposons that can achieve a balance between their own replication and minimal damage to their host. Epigenetic regulation proves to be a widespread way to achieve this balance, quieting transposition on the one hand, yet reversible on the other. As our understanding of epigenetics improves, the subtleties and the scope of how transposons can affect gene expression, both directly and indirectly, are becoming clearer.
转座子通过移动进行复制、增加拷贝数并在自然界中持续存在,但插入基因通常具有致突变性。因此,对于能够在自身复制与对宿主造成最小损害之间取得平衡的转座子,存在着强烈的选择压力。事实证明,表观遗传调控是实现这种平衡的一种广泛方式,一方面使转座作用沉默,另一方面又具有可逆性。随着我们对表观遗传学的理解不断深入,转座子如何直接和间接地影响基因表达的细微之处和范围正变得越来越清晰。