Numasaki Y, Takahashi K, Masuda E, Nohara C, Maeda H
Department of Research II, Yamanouchi Pharmaceutical Co., Tokyo, Japan.
Gan To Kagaku Ryoho. 1991 Oct;18(13):2289-94.
Zinostatin stimalamer (YM881) is an antitumor agent, chemically synthesized by coupling one molecule of neocarzinostatin (NCS), with 2 molecules of styrene maleic acid half-butylester copolymer. YM881 showed strong cytotoxicity to human (KB, ST4 and others) and mouse (P388, L1210) tumor cell lines and also drug-resistant tumor cell lines. The antitumor effects were observed in murine MM46, colon 26 and other tumor models. The antitumor activity was as effective as NCS or better than NCS at the effective dose ranges.
制癌菌素斯替马兰（YM881）是一种抗肿瘤药物，通过将一分子新制癌菌素（NCS）与两分子苯乙烯马来酸半丁酯共聚物偶联化学合成。YM881对人（KB、ST4等）和小鼠（P388、L1210）肿瘤细胞系以及耐药肿瘤细胞系显示出强大的细胞毒性。在小鼠MM46、结肠癌26和其他肿瘤模型中观察到了抗肿瘤作用。在有效剂量范围内，其抗肿瘤活性与NCS相当或优于NCS。
Zotero 插件