Kimura M, Konno T, Ohtsuka N, Mizumachi R, Oda T
Dept. of Surgery Kumamoto University Medical School.
Gan To Kagaku Ryoho. 1989 Jun;16(6):2183-8.
YM881 (MW 15,000) is a conjugate protein preparation of two copolymer of styrene-maleic acid [SMA] (MW 1,500) and neocarzinostatin [NCS] (MW 12,000). Antitumor activities of YM881 and NCS with or without oily solvent injected arterially against VX2 carcinoma of rabbits were examined. Based on the growth and histological examination of the tumor, remarkable anti-tumor activities were observed with oily suspended YM881 but not with the other group. This results indicate that targeting of the anticancer agent to the tumor is most important for eliciting of antitumor activities.
YM881（分子量15,000）是由两种共聚物组成的结合蛋白制剂，即苯乙烯 - 马来酸[SMA]（分子量1,500）和新制癌菌素[NCS]（分子量12,000）。研究了YM881和NCS在有或没有油性溶剂动脉注射的情况下对兔VX2癌的抗肿瘤活性。基于肿瘤的生长和组织学检查，观察到油性悬浮的YM881具有显著的抗肿瘤活性，而其他组则没有。这些结果表明，将抗癌剂靶向肿瘤对于发挥抗肿瘤活性最为重要。
