Chibana T, Nagamine F, Sunagawa R, Oshiro K, Nakada Y, Shimabukuro M, Shinzato T, Murakami K, Mimura G, Sakanashi M
Second Department of Internal Medicine, School of Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Arzneimittelforschung. 1991 Jun;41(6):591-4.
Acute hemodynamic and coronary vasodilating effects of nicorandol (SG-75, Sigmat; CAS 65141-46-0) and glyceryl trinitrate (GTN, nitroglycerin) were examined in 20 subjects under cardiac catheterization and coronary arteriography. Nicorandil 4 mg i.v. produced significant increases in heart rate, cardiac index and stroke volume index and significant decreases in systolic, diastolic and mean blood pressure, pulmonary capillary wedge pressure, left ventricular enddiastolic pressure, systemic vascular resistance and total pulmonary resistance. Degree of percent changes in these parameters by nicorandil were similar to that by GTN 0.3 mg i.v. Coronary vasodilating effects of both drugs were also at the same degree. Results indicate that nicorandil has cardiovascular and coronary vasodilating effects similar to those of GTN when administered intravenously.
在20例接受心导管检查和冠状动脉造影的受试者中，研究了尼可地尔（SG-75，西格玛；化学物质登记号65141-46-0）和硝酸甘油（GTN，硝酸甘油）的急性血流动力学和冠状动脉舒张作用。静脉注射4毫克尼可地尔可使心率、心脏指数和每搏量指数显著增加，使收缩压、舒张压和平均血压、肺毛细血管楔压、左心室舒张末期压力、全身血管阻力和总肺阻力显著降低。尼可地尔引起的这些参数的百分比变化程度与静脉注射0.3毫克GTN相似。两种药物的冠状动脉舒张作用程度也相同。结果表明，静脉给药时，尼可地尔具有与GTN相似的心血管和冠状动脉舒张作用。
