正常眼压性青光眼患者从局部用β受体阻滞剂转换为拉坦前列素对眼压的影响。

Effects of switching from topical beta-blockers to latanoprost on intraocular pressure in patients with normal-tension glaucoma.

作者信息

Ikeda Yoko, Mori Kazuhiko, Ishibashi Takeshi, Naruse Shigeta, Nakajima Nobuko, Kinoshita Shigeru

机构信息

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

出版信息

J Ocul Pharmacol Ther. 2008 Apr;24(2):230-4. doi: 10.1089/jop.2007.0016.

DOI:10.1089/jop.2007.0016

PMID:18341431

Abstract

AIMS

The effects of switching from topical beta-blockers (beta) to latanoprost (LA) on intraocular pressure (IOP) and IOP-reduction rate (IOP-RR) in patients with normal-tension glaucoma (NTG) were investigated.

SUBJECTS AND METHODS

Sixty (60) NTG patients (60 eyes) were divided into three equal groups receiving carteolol hydrochloride (group A), nipradilol (group B), and betaxolol hydrochloride (group C) twice-daily for 3 months. The drugs were changed to topical LA administered once-daily for the next 3 months.

RESULTS

Baseline IOP was 14.4 +/- 0.9, 14.6 +/- 0.6, and 14.6 +/- 0.9 mmHg in groups A, B, and C, respectively. At 3 months, IOP was 12.4 +/- 0.6, 13.4 +/- 0.6, and 12.9 +/- 0.8 mmHg and 10.5 +/- 0.5, 11.1 +/- 0.8, and 11.7 +/- 0.8 mmHg at 6 months in groups A, B, and C, respectively. At 3 months, IOP-RR was 10.4 +/- 5.5, 9.5 +/- 2.6, and 10.8 +/- 4.7% and 24.1 +/- 4.3, 22.9 +/- 5.9, and 19.4 +/- 3.8% at 6 months in groups A, B, and C, respectively. The groups did not significantly differ in the first 3 months regarding IOP and IOP-RR. Switching to LA significantly decreased IOP and increased IOP-RR in all groups.

CONCLUSION

In NTG patients, LA reduced IOP more effectively than the beta tested.

摘要

目的

研究正常眼压性青光眼（NTG）患者从局部使用β受体阻滞剂（β）转换为拉坦前列素（LA）对眼压（IOP）和眼压降低率（IOP - RR）的影响。

对象与方法

60例NTG患者（60只眼）被平均分为三组，分别每日两次接受盐酸卡替洛尔（A组）、尼普地洛（B组）和盐酸倍他洛尔（C组）治疗，为期3个月。在接下来的3个月里，将药物更换为每日一次的局部LA治疗。

结果

A、B、C组的基线眼压分别为14.4±0.9、14.6±0.6和14.6±0.9 mmHg。3个月时，A、B、C组的眼压分别为12.4±0.6、13.4±0.6和12.9±0.8 mmHg；6个月时分别为10.5±0.5、11.1±0.8和11.7±0.8 mmHg。3个月时，A、B、C组的IOP - RR分别为10.4±5.5、9.5±2.6和10.8±4.7%；6个月时分别为24.1±4.3、22.9±5.9和19.4±3.8%。在最初3个月，各组在眼压和IOP - RR方面无显著差异。转换为LA后，所有组的眼压均显著降低，IOP - RR均显著升高。