Godfrey Dale I, Rossjohn Jamie, McCluskey James
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia.
Immunity. 2008 Mar;28(3):304-14. doi: 10.1016/j.immuni.2008.02.004.
Although there are multiple structures showing how alphabeta T cell receptors (TCRs) specifically recognize antigenic peptides bound to the major histocompatibility complex (MHC) molecules (pMHC-I and pMHC-II), we have little data on how TCRs interact with lipid-based antigens presented by members of the CD1 family. Here, we review recent findings in the field of TCR recognition, including TCR-pMHC complexes and the structure of a TCR in complex with CD1d-glycolipid. Collectively, these studies have revealed the versatility of the TCR in recognizing the distinct yet evolutionarily related proteinaceous and lipid-presenting molecules of the immune system.
尽管有多种结构展示了αβ T细胞受体（TCR）如何特异性识别与主要组织相容性复合体（MHC）分子（pMHC-I和pMHC-II）结合的抗原肽，但我们对于TCR如何与CD1家族成员呈递的基于脂质的抗原相互作用的数据却很少。在此，我们综述了TCR识别领域的最新发现，包括TCR-pMHC复合物以及与CD1d-糖脂形成复合物的TCR的结构。总体而言，这些研究揭示了TCR在识别免疫系统中独特但在进化上相关的蛋白质和脂质呈递分子方面的多功能性。
