Pons-Guiraud A
10, Boulevard Malesherbes, 75008, Paris, France.
Ann Dermatol Venereol. 2008 Feb;135 Suppl 3:S171-4. doi: 10.1016/S0151-9638(08)70076-0.
The number of "fillers" grows constantly and allows responding to an ever larger demand with mostly hyaluronic acid or collagen based products. However, products degrading more slowly, containing polylactic acid or bioactive ceramics. All these products bring in general satisfactory results. Their short term tolerance shows few side effects, benign and always reversible. Long term, foreign body granulomas are very rare if interrogation prior to patient's treatment is exhaustive. On the reverse, non degradable products are at the origin of unaesthetic and invalidating granulomas, often very delayed and resisting to various local treatments. For this reason, these products should not be used anymore or only very exceptionally, for soft tissue augmentation.
“填充剂”的种类不断增加,能够满足对大多基于透明质酸或胶原蛋白产品日益增长的需求。然而,还有降解更缓慢的产品,含有聚乳酸或生物活性陶瓷。所有这些产品总体上都能带来令人满意的效果。它们的短期耐受性良好,副作用很少,且都是良性且可逆的。从长期来看,如果在患者治疗前进行详尽的问诊,异物肉芽肿非常罕见。相反,不可降解产品会导致不美观且致残的肉芽肿,通常出现得很迟且对各种局部治疗都有抵抗性。因此,这些产品不应再使用,或仅在极为特殊的情况下用于软组织填充。