Akrish Sharon, Dayan Dan, Taicher Shlomo, Adam Iris, Nagler Rafael M
Department Oral Pathology and Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
Am J Otolaryngol. 2009 Sep-Oct;30(5):356-9. doi: 10.1016/j.amjoto.2008.07.001. Epub 2009 Mar 6.
Bio-alcamid is one of the newest agents on the market for soft tissue augmentation. Seven studies were documented in the medical literature that examined the safety of Bio-alcamid (Polymekon, Brindisy, Italy); all reported no cases of tissue migration, foreign body granulomas, allergenicity, or interference with the control of cell proliferation. On 2 separate occasions, a woman who had recently undergone lip augmentation presented at our hospital with submucosal nodules of the lip. Histologic examination revealed multiple foreign body-type granulomas composed of giant cells, epithelioid cells, and chronic inflammation of the lip. Efforts to produce a cosmetic material that fulfills all the criteria as an "ideal" agent has not yet been found because all injectable foreign agents have the potential to induce adverse reactions. Caution must be exercised in all cases and the risks explained to the patient before its use.
Bio-alcamid是市场上用于软组织填充的最新制剂之一。医学文献中记录了7项研究，这些研究检测了Bio-alcamid（Polymekon，布林迪西，意大利）的安全性；所有研究均报告未出现组织迁移、异物肉芽肿、致敏性或对细胞增殖控制产生干扰的病例。在两个不同的场合，一名近期接受过隆唇手术的女性因唇部黏膜下结节前来我院就诊。组织学检查显示唇部有多个由巨细胞、上皮样细胞组成的异物型肉芽肿以及慢性炎症。由于所有可注射的外来制剂都有可能引发不良反应，因此尚未找到一种能满足作为“理想”制剂所有标准的美容材料。在所有情况下都必须谨慎行事，并在使用前向患者解释风险。
