接受强化糖尿病治疗的妊娠期糖尿病女性中影响巨大儿风险的因素。

Factors influencing risk of macrosomia in women with gestational diabetes mellitus undergoing intensive diabetic care.

作者信息

Ogonowski Jarosław, Miazgowski Tomasz, Czeszyńska Maria B, Jaskot Brygida, Kuczyńska Magdalena, Celewicz Zbigniew

机构信息

Department of Endocrinology, Metabolic Diseases and Internal Diseases, Pomeranian Medical University, Ul. Arkońska 4, 71-455 Szczecin, Poland.

出版信息

Diabetes Res Clin Pract. 2008 Jun;80(3):405-10. doi: 10.1016/j.diabres.2008.01.017. Epub 2008 Mar 14.

DOI:10.1016/j.diabres.2008.01.017

PMID:18342386

Abstract

AIMS

The aim of study was to assess the impact of intensive diabetic care, defined as target values for fasting glucose of 60-90mg/dl and 1-h postprandial glucose of below 130mg/dl, on neonatal birth weight in relation to risk indicators for fetal macrosomia in women with gestational diabetes mellitus (GDM).

METHODS

In women with (N=543) and without GDM (N=1011) age, height, weight, previous GDM, history of macrosomia, family history of type 2 diabetes, parity and weight gain during pregnancy were recorded.

RESULTS

Neonatal birth weight and frequency distribution of macrosomia and infants with small for gestational age did not differ between women with and without GDM. Neonatal birth weight was strongly associated with traditional risk predictors for GDM, such like prior macrosomia (OR 5.03; 95%CI 3.36-7.53), prior GDM (OR 2.52; 95%CI 1.37-4.64) and prepregnancy body mass index (BMI)>23kg/m(2) (OR 1.82; 95%CI 1.27-2.63).

CONCLUSIONS

Neonatal birth weight and the incidence of macrosomia were similar in comparison of pregnancies with and without GDM. In the population of Caucasian women the strongest single predictors for macrosomia were prior macrosomia, BMI>23kg/m(2) and prior GDM.

摘要

目的

本研究旨在评估强化糖尿病护理（定义为空腹血糖目标值为60 - 90mg/dl且餐后1小时血糖低于130mg/dl）对妊娠糖尿病（GDM）女性新生儿出生体重以及巨大儿风险指标的影响。

方法

记录患有GDM（N = 543）和未患GDM（N = 1011）女性的年龄、身高、体重、既往GDM史、巨大儿病史、2型糖尿病家族史、产次及孕期体重增加情况。

结果

患GDM和未患GDM的女性新生儿出生体重、巨大儿及小于胎龄儿的频率分布无差异。新生儿出生体重与GDM的传统风险预测因素密切相关，如既往巨大儿（OR 5.03；95%CI 3.36 - 7.53）、既往GDM（OR 2.52；95%CI 1.37 - 4.64）及孕前体重指数（BMI）>23kg/m²（OR 1.82；95%CI 1.27 - 2.63）。