Miller A D, Alcaraz A, McDonough S P
Department of Biomedical Sciences, Section of Anatomic Pathology, Cornell University, Ithaca, NY, USA.
J Comp Pathol. 2008 May;138(4):215-7. doi: 10.1016/j.jcpa.2007.12.003. Epub 2008 Mar 17.
A female spayed cocker spaniel dog, aged 8 years, developed a large, smooth pedunculated mass arising from the right palatine tonsil. Histology revealed that the mass was composed of many, variably dilated, thin-walled lymphatic channels filled with pale eosinophilic fluid lacking red blood cells and embedded in a dense, fibrovascular stroma. The dilated lymphatic channels were lined by a single layer of flattened, discontinuous endothelium with scattered intraluminal valves. Periodic acid-Schiff staining highlighted the discontinuous basement membrane and immunohistochemistry revealed strong cell membrane and cytoplasmic immunoreactivity for CD31 and von Willebrand factor, respectively. The clinical and histological findings were consistent with a tonsillar lymphangiomatous polyp - an uncommon, benign tumour of the tonsil in man that has previously been unrecognized in veterinary medicine.
一只8岁的雌性去势可卡犬出现了一个从右侧腭扁桃体长出的、光滑带蒂的大肿块。组织学检查显示，该肿块由许多大小不一、薄壁扩张的淋巴管组成，管腔内充满缺乏红细胞的淡嗜酸性液体，并嵌入致密的纤维血管基质中。扩张的淋巴管内衬单层扁平、不连续的内皮细胞，管腔内有散在的瓣膜。过碘酸-希夫染色突出显示了不连续的基底膜，免疫组织化学分别显示CD31和血管性血友病因子在细胞膜和细胞质中有强免疫反应性。临床和组织学检查结果符合扁桃体淋巴管瘤性息肉——一种在人类中罕见的扁桃体良性肿瘤，此前在兽医学中未被认识到。
