de Visser Karin E
Department of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Cancer Immunol Immunother. 2008 Oct;57(10):1531-9. doi: 10.1007/s00262-008-0501-x. Epub 2008 Mar 15.
Cancer cells cannot develop into invasive cancers without interactions with cells and soluble mediators present in the tumor microenvironment. Accumulating evidence indicates that the immune system is a critical determinant of malignant outgrowth; however, the tumor-modulating effects of spontaneous immune responses towards nascent malignancies are rather paradoxical. Both cancer-protective and cancer-promoting features of the immune system have been described. This review will discuss the role of the dynamic inflammatory tumor microenvironment during cancer development and progression, and will focus on the intriguing question: "Do malignancies develop in spite of-or because of-spontaneous immune responses?" Special emphasis will be put on recent progress in our understanding of the immune system's double-edged sword function during de novo carcinogenesis.
癌细胞如果不与肿瘤微环境中的细胞及可溶性介质相互作用,就无法发展成侵袭性癌症。越来越多的证据表明,免疫系统是恶性肿瘤生长的关键决定因素;然而,针对新生恶性肿瘤的自发免疫反应对肿瘤的调节作用却相当矛盾。免疫系统的抗癌和促癌特性均有报道。本综述将讨论动态炎性肿瘤微环境在癌症发生和发展过程中的作用,并聚焦于这个有趣的问题:“恶性肿瘤的发生是尽管有自发免疫反应——还是因为有自发免疫反应?”将特别强调我们在理解免疫系统在肿瘤起始过程中的双刃剑功能方面的最新进展。