Jager Pieter L, Chirakal Raman, Marriott Christopher J, Brouwers Adrienne H, Koopmans Klaas Pieter, Gulenchyn Karen Y
Department of Nuclear Medicine, Hamilton Health Sciences/McMaster University, Hamilton, Ontario, Canada.
J Nucl Med. 2008 Apr;49(4):573-86. doi: 10.2967/jnumed.107.045708. Epub 2008 Mar 14.
In recent years, 6-l-18F-fluorodihydroxyphenylalanine (18F-DOPA) PET has emerged as a new diagnostic tool for the imaging of neuroendocrine tumors. This application is based on the unique property of neuroendocrine tumors to produce and secrete various substances, a process that requires the uptake of metabolic precursors, which leads to the uptake of 18F-DOPA. This nonsystematic review first describes basic aspects of 18F-DOPA imaging, including radiosynthesis, factors involved in tracer uptake, and various aspects of metabolism and imaging. Subsequently, this review provides an overview of current clinical applications in neuroendocrine tumors, including carcinoid tumors, pancreatic islet cell tumors, pheochromocytoma, paraganglioma, medullary thyroid cancer, hyperinsulinism, and various other clinical entities. The application of PET/CT in carcinoid tumors has unsurpassed sensitivity. In medullary thyroid cancer, pheochromocytoma, and hyperinsulinism, results are also excellent and contribute significantly to clinical management. In the remaining conditions, the initial experience with 18F-DOPA PET indicates that it seems to be less valuable, but further study is required.
近年来，6-1-18F-氟二羟基苯丙氨酸（18F-DOPA）正电子发射断层显像（PET）已成为一种用于神经内分泌肿瘤成像的新型诊断工具。该应用基于神经内分泌肿瘤产生和分泌各种物质的独特特性，这一过程需要摄取代谢前体，从而导致18F-DOPA的摄取。这篇非系统性综述首先描述了18F-DOPA成像的基本方面，包括放射性合成、示踪剂摄取所涉及的因素以及代谢和成像的各个方面。随后，本综述概述了18F-DOPA在神经内分泌肿瘤中的当前临床应用，包括类癌肿瘤、胰岛细胞瘤、嗜铬细胞瘤、副神经节瘤、甲状腺髓样癌、高胰岛素血症以及各种其他临床实体。PET/CT在类癌肿瘤中的应用具有无与伦比的敏感性。在甲状腺髓样癌、嗜铬细胞瘤和高胰岛素血症中，结果也非常出色，对临床管理有显著贡献。在其余情况下，18F-DOPA PET的初步经验表明其价值似乎较低，但仍需要进一步研究。
