一种老药的新用途：mTOR抑制剂雷帕霉素通过诱导细胞衰老增强氟尿嘧啶对肝细胞癌的疗效。 - Suppr

A new trick for an old drug: mTOR inhibitor rapamycin augments the effect of fluorouracil on hepatocellular carcinoma by inducing cell senescence.

作者信息

Shi Yufang, August David A

机构信息

Department of Molecular Genetics, Microbiology and Immunology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ, USA.

出版信息

Cancer Biol Ther. 2008 Mar;7(3):397-8. doi: 10.4161/cbt.7.3.5871. Epub 2008 Mar 10.

DOI:10.4161/cbt.7.3.5871

PMID:18344684

Abstract

摘要

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A new trick for an old drug: mTOR inhibitor rapamycin augments the effect of fluorouracil on hepatocellular carcinoma by inducing cell senescence.一种老药的新用途：mTOR抑制剂雷帕霉素通过诱导细胞衰老增强氟尿嘧啶对肝细胞癌的疗效。

Cancer Biol Ther. 2008 Mar;7(3):397-8. doi: 10.4161/cbt.7.3.5871. Epub 2008 Mar 10.

Synergistic effect of mTOR inhibitor rapamycin and fluorouracil in inducing apoptosis and cell senescence in hepatocarcinoma cells.mTOR抑制剂雷帕霉素与氟尿嘧啶在诱导肝癌细胞凋亡和细胞衰老中的协同作用。

Cancer Biol Ther. 2008 Mar;7(3):392-6. doi: 10.4161/cbt.7.3.5366. Epub 2007 Dec 2.

Rapamycin and CCI-779 inhibit the mammalian target of rapamycin signalling in hepatocellular carcinoma.雷帕霉素和 CCI-779 抑制肝癌中的哺乳动物雷帕霉素靶蛋白信号通路。

Liver Int. 2010 Jan;30(1):65-75. doi: 10.1111/j.1478-3231.2009.02117.x. Epub 2009 Oct 20.

PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation.靶向PI3K/AKT/mTOR和Ras/Raf/MAPK通路的PKI-587与索拉非尼协同抑制肝癌细胞增殖。

J Surg Res. 2012 Aug;176(2):542-8. doi: 10.1016/j.jss.2011.10.045. Epub 2011 Nov 21.

[The interaction between 5-fluorouracil and marini on QGY cell line in vitro].[5-氟尿嘧啶与马里尼对QGY细胞系的体外相互作用]

Zhonghua Gan Zang Bing Za Zhi. 2002 Apr;10(2):160.

The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma.胰岛素和胰岛素样生长因子1受体的双重靶向增强了mTOR抑制剂在肝细胞癌中介导的抗肿瘤疗效。

Oncotarget. 2016 Mar 1;7(9):9718-31. doi: 10.18632/oncotarget.6836.

Benchmarking effects of mTOR, PI3K, and dual PI3K/mTOR inhibitors in hepatocellular and renal cell carcinoma models developing resistance to sunitinib and sorafenib.比较 mTOR、PI3K 及双重 PI3K/mTOR 抑制剂在对舒尼替尼和索拉非尼产生耐药的肝癌和肾癌模型中的疗效。

Cancer Chemother Pharmacol. 2013 May;71(5):1297-307. doi: 10.1007/s00280-013-2129-6. Epub 2013 Mar 12.

Coupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma cells.氟尿嘧啶诱导肝癌细胞凋亡过程中mTOR与端粒酶活性的协同下调

BMC Cancer. 2007 Nov 12;7:208. doi: 10.1186/1471-2407-7-208.

[Research advances in the mammalian target of rapamycin signaling pathway and its inhibitors in treatment of hepatocellular carcinoma].雷帕霉素哺乳动物靶点信号通路及其抑制剂在肝细胞癌治疗中的研究进展

Zhonghua Gan Zang Bing Za Zhi. 2018 Jan 20;26(1):77-80. doi: 10.3760/cma.j.issn.1007-3418.2018.01.018.

Gerosuppression by pan-mTOR inhibitors.泛mTOR抑制剂对衰老的抑制作用。

Aging (Albany NY). 2016 Dec 30;8(12):3535-3551. doi: 10.18632/aging.101155.

引用本文的文献

Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice.用雷帕霉素对小鼠进行慢性mTOR抑制会改变T细胞、B细胞、髓样细胞、固有淋巴细胞和肠道菌群，并延长免疫缺陷小鼠的寿命。

Aging Cell. 2015 Dec;14(6):945-56. doi: 10.1111/acel.12380. Epub 2015 Aug 28.

Interferon-α enhances the susceptibility of renal cell carcinoma to rapamycin by suppressing mTOR activity.干扰素-α 通过抑制 mTOR 活性增强肾细胞癌对雷帕霉素的敏感性。

Exp Ther Med. 2014 Jul;8(1):267-273. doi: 10.3892/etm.2014.1691. Epub 2014 Apr 25.

The inhibitory effect of rapamycin on the oval cell response and development of preneoplastic foci in the rat.雷帕霉素对大鼠卵圆细胞反应和前瘤性病灶发展的抑制作用。

Exp Mol Pathol. 2012 Aug;93(1):40-9. doi: 10.1016/j.yexmp.2012.04.002. Epub 2012 Apr 16.

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A new trick for an old drug: mTOR inhibitor rapamycin augments the effect of fluorouracil on hepatocellular carcinoma by inducing cell senescence.

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