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[一名患有多发性硬化症患者的尿崩症]

[Diabetes insipidus in a pacient with multiple sclerosis].

作者信息

Weiler Fernanda G, Blumberg Kátia, Liboni Claudia S, Roque Eduardo A C, Góis Aécio F T de

机构信息

Disciplina de Medicina de Urgência, Universidade Federal de São Paulo, Brazil.

出版信息

Arq Bras Endocrinol Metabol. 2008 Feb;52(1):134-7. doi: 10.1590/s0004-27302008000100020.

Abstract

Multiple Sclerosis (ME) is a chronic progressive disease characterized by relapses of demyelination that can occur anywhere in the brain stem, spinal cord and optic nerve. Since central diabetes insipidus (DI) is mainly caused by central nervous system damage (such as trauma, surgery, tumor, infection, sarcoidosis), ME is included among its possible etiologies. However, this association is not commonly described. The clinical suspicion must be made in the presence of polyuria and polydipsia or refractory hypernatremia (in patients without free access to water) during the evolution of ME. We will describe a clinical report in which this association occurred and, after the beginning of desmopressin therapy, the clinical findings were reverted.

摘要

多发性硬化症(ME)是一种慢性进行性疾病,其特征是脱髓鞘复发,可发生在脑干、脊髓和视神经的任何部位。由于中枢性尿崩症(DI)主要由中枢神经系统损伤(如创伤、手术、肿瘤、感染、结节病)引起,ME被列为其可能的病因之一。然而,这种关联并不常见。在ME病程中,当出现多尿、烦渴或难治性高钠血症(在无水自由摄入的患者中)时,必须进行临床怀疑。我们将描述一份临床报告,其中发生了这种关联,并且在开始去氨加压素治疗后,临床症状得到了逆转。

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