De Angelis P, Morino G, Pane A, Torroni F, Francalanci P, Sabbi T, Foschia F, Caldaro T, di Abriola G Federici, Dall'Oglio L
Pediatric Hospital Bambino Gesù, Digestive Surgery and Endoscopy Unit, IRCCS, Piazza S. Onofrio, 4-00165 Rome, Italy.
Expert Opin Pharmacother. 2008 Apr;9(5):731-40. doi: 10.1517/14656566.9.5.731.
Eosinophilic esophagitis represents the most debated disease of the last 10 years, too often speculated or overestimated and certainly well known and examined. The aim of this study was to summarize the recent therapeutic trends in order to show persistent doubts regarding several debated therapies. The study combined the most recent international literature and the authors' daily experience to define the scope of the review, with limits caused by a lack of available randomized studies between dietetic and pharmacological treatment. It was concluded that eosinophilic esophagitis is an immunoallergic disease that is generally caused by identifiable food and environmental allergens although, in a minority of cases, the etiological trigger remains undetermined. Therapy usually fights the responsible agents, but sometimes they are not resolved. A need for more pathogenetically driven treatments is invoked.
嗜酸性粒细胞性食管炎是过去10年中争议最大的疾病，常常被过度推测或高估，当然也是广为人知且经过充分研究的。本研究的目的是总结近期的治疗趋势，以表明对于几种有争议的治疗方法仍存在持续的疑问。该研究结合了最新的国际文献和作者的日常经验来确定综述的范围，由于饮食和药物治疗之间缺乏可用的随机研究，存在一定局限性。研究得出结论，嗜酸性粒细胞性食管炎是一种免疫过敏性疾病，通常由可识别的食物和环境过敏原引起，尽管在少数情况下，病因触发因素仍未确定。治疗通常针对致病因素，但有时这些因素无法消除。人们呼吁需要更多基于发病机制的治疗方法。
