坦索罗辛缓释片和口服控释吸收系统（OCAS）：当前的治疗用途。
Tamsulosin MR and OCAS (modified release and oral controlled absorption system): current therapeutic uses.
作者信息
Nargund Vinod H, Grey Alistair D R
机构信息
St Bartholomew's Hospital, Department of Genito-Urinary Surgery, West Smithfield, London EC1A 7BE, UK.
出版信息
Expert Opin Pharmacother. 2008 Apr;9(5):813-24. doi: 10.1517/14656566.9.5.813.
BACKGROUND
Although tamsulosin is mainly used to treat lower urinary tract symptoms secondary to benign prostatic hyperplasia, with better understanding of functional anatomy and distribution of alpha(1) receptors, it is also indicated in other conditions of genito-urinary tract in both men and women.
OBJECTIVE
To detail the therapeutic use and clinical effects of tamsulosin.
METHODS
The scope of the review was related to tamsulosin and its therapeutic application in conditions of genitourinary tract. Publications were searched from Pubmed and Medline from 1975 to 2007 using the search words tamsulosin, lower urinary tract symptoms, alpha receptors and blockers.
CONCLUSIONS
The management of benign prostatic hyperplasia was transurethral resection of prostate until simpler and alternative treatments were tried in the last two decades, particularly alpha(1) adrenoceptor-blocking agents. Tamsulosin is a potent, third-generation selective alpha(1A) adrenoceptor-blocking agent.
背景
尽管坦索罗辛主要用于治疗良性前列腺增生继发的下尿路症状，但随着对α(1)受体功能解剖和分布的深入了解，它也被用于男性和女性泌尿生殖道的其他疾病。
目的
详细阐述坦索罗辛的治疗用途和临床效果。
方法
综述范围涉及坦索罗辛及其在泌尿生殖道疾病中的治疗应用。使用搜索词坦索罗辛、下尿路症状、α受体和阻滞剂，从1975年至2007年的PubMed和Medline数据库中检索相关出版物。
结论
在过去二十年尝试采用更简单的替代治疗方法之前，良性前列腺增生的治疗方法是经尿道前列腺切除术，尤其是α(1)肾上腺素能受体阻滞剂。坦索罗辛是一种强效的第三代选择性α(1A)肾上腺素能受体阻滞剂。
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