Kusztal Mariusz, Kosmaczewska Agata, Magott-Procelewska Maria, Frydecka Irena, Ciszak Lidia, Bocko Dorota, Patrzalek Dariusz, Klinger Marian
Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.
Transpl Int. 2008 Jul;21(7):661-8. doi: 10.1111/j.1432-2277.2008.00663.x. Epub 2008 Mar 13.
There is a growing body of evidence showing that the intensity of rejection is weaker in older kidney allograft recipients while chronic complications, but not rejection, are the main causes of graft loss. To investigate whether the age of the recipient is a factor affecting the expressions of the CD28, CTLA-4, and CD40L costimulatory molecules on CD4+ T cells. Their expression levels were determined in 78 kidney transplant recipients aged 17-68 years. The expression was assessed on unstimulated and anti-CD3 antibody + IL-2-stimulated CD4+ T cells. Median time after transplantation was 20 months and median serum creatinine was 1.5 mg/dl. Significant correlations between age and CD28 expression (r = -0.4, P = 0.0004) on CD4+ T cells and between age and CTLA-4 expression after stimulation (r = 0.34, P = 0.008) were found. CD40L expression on CD4+ T cells was not affected by recipient age. The decreased expression of CD28 and enhanced expression of CTLA-4 (after stimulation) associated with age may be helpful in transplant acceptance.
越来越多的证据表明，老年肾移植受者的排斥反应强度较弱，而慢性并发症而非排斥反应是移植物丢失的主要原因。为了研究受者年龄是否是影响CD4+T细胞上共刺激分子CD28、CTLA-4和CD40L表达的一个因素。在78名年龄在17至68岁的肾移植受者中测定了它们的表达水平。在未刺激的以及抗CD3抗体+IL-2刺激的CD4+T细胞上评估表达情况。移植后的中位时间为20个月，中位血清肌酐为1.5mg/dl。发现年龄与CD4+T细胞上的CD28表达之间存在显著相关性（r = -0.4，P = 0.0004），以及年龄与刺激后CTLA-4表达之间存在显著相关性（r = 0.34，P = 0.008）。CD4+T细胞上的CD40L表达不受受者年龄影响。与年龄相关的CD28表达降低和CTLA-4表达增强（刺激后）可能有助于移植接受。
