来自构巢曲霉的降红杉醇酸通过Fas介导的途径抑制人乳腺腺癌MCF-7细胞的增殖。
Norsolorinic acid from Aspergillus nidulans inhibits the proliferation of human breast adenocarcinoma MCF-7 cells via Fas-mediated pathway.
作者信息
Wang Clay C C, Chiang Yi-Ming, Kuo Po-Lin, Chang Jiunn-Kae, Hsu Ya-Ling
机构信息
Department of Pharmacology and Pharmaceutical Science, School of Pharmacy, University of Southern California, Los Angeles, CA, USA.
出版信息
Basic Clin Pharmacol Toxicol. 2008 Jun;102(6):491-7. doi: 10.1111/j.1742-7843.2008.00237.x. Epub 2008 Mar 16.
Abstract
Norsolorinic acid, isolated from the Aspergillus nidulans, was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. To identity the anticancer mechanism of norsolorinic acid, we assayed its effect on apoptosis, cell cycle distribution, and levels of p53, p21/WAF1, Fas/APO-1 receptor and Fas ligand. The results showed that norsolorinic acid induced apoptosis of MCF-7 cells without mediation of p53 and p21/WAF1. We suggest that Fas/Fas ligand apoptotic system is the main pathway of norsolorinic acid-mediated apoptosis of MCF-7 cells. Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of norsolorinic acid in MCF-7 cells.
摘要
从构巢曲霉中分离出的降红曲酸，对其在人乳腺腺癌MCF-7细胞中的抗增殖活性进行了研究。为了确定降红曲酸的抗癌机制，我们检测了其对细胞凋亡、细胞周期分布以及p53、p21/WAF1、Fas/APO-1受体和Fas配体水平的影响。结果表明，降红曲酸可诱导MCF-7细胞凋亡，且不依赖p53和p21/WAF1的介导。我们认为，Fas/Fas配体细胞凋亡系统是降红曲酸介导MCF-7细胞凋亡的主要途径。我们的研究首次报道，Fas/Fas配体细胞凋亡系统的活性可能参与了降红曲酸在MCF-7细胞中的抗增殖活性。
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