Miller Gad, Shulaev Vladimir, Mittler Ron
Department of Biochemistry and Molecular Biology, University of Nevada, MS200, Reno, NV 89557, USA.
Physiol Plant. 2008 Jul;133(3):481-9. doi: 10.1111/j.1399-3054.2008.01090.x. Epub 2008 Jul 1.
Reactive oxygen species (ROS) play a dual role in plant biology acting on the one hand as important signal transduction molecules and on the other as toxic by-products of aerobic metabolism that accumulate in cells during different stress conditions. Because of their toxicity as well as their important signaling role, the level of ROS in cells is tightly controlled by a vast network of genes termed the 'ROS gene network'. Using mutants deficient in key ROS-scavenging enzymes, we have defined a signaling pathway that is activated in cells in response to ROS accumulation. Interestingly, many of the key players in this pathway, including different zinc finger proteins and WRKY transcription factors, are also central regulators of abiotic stress responses involved in temperature, salinity and osmotic stresses. Here, we describe our recent findings and discuss how ROS integrate different signals originating from different cellular compartments during abiotic stress.
活性氧（ROS）在植物生物学中发挥着双重作用，一方面作为重要的信号转导分子，另一方面作为有氧代谢的有毒副产物，在不同胁迫条件下在细胞中积累。由于它们的毒性及其重要的信号作用，细胞中的ROS水平由一个称为“ROS基因网络”的庞大基因网络严格控制。利用缺乏关键ROS清除酶的突变体，我们定义了一条在细胞中因ROS积累而被激活的信号通路。有趣的是，这条通路中的许多关键参与者，包括不同的锌指蛋白和WRKY转录因子，也是参与温度、盐度和渗透胁迫的非生物胁迫反应的核心调节因子。在这里，我们描述我们最近的发现，并讨论ROS如何在非生物胁迫期间整合来自不同细胞区室的不同信号。
